General Information:

Id: 2,507
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Kipnis E et al.(2006) Targeting mechanisms of Pseudomonas aeruginosa pathogenesis. Med Mal Infect 36: 78-91 [PMID: 16427231]

Interaction Information:

Comment P. aeruginosa protease IV is involved in the pathogenesis of lung infection through degradation of surfactant proteins A, D and B.
Formal Description
Interaction-ID: 23344

gene/protein

piv

decreases_quantity of

gene/protein

SFTPA1

Drugbank entries Show/Hide entries for SFTPA1
Comment P. aeruginosa protease IV is involved in the pathogenesis of lung infection through degradation of surfactant proteins A, D and B.
Formal Description
Interaction-ID: 23346

gene/protein

piv

decreases_quantity of

gene/protein

SFTPD

Drugbank entries Show/Hide entries for SFTPD
Comment P. aeruginosa protease IV is involved in the pathogenesis of lung infection through degradation of surfactant proteins A, D and B.
Formal Description
Interaction-ID: 23347

gene/protein

piv

decreases_quantity of

gene/protein

SFTPB

Comment P. aeruginosa elastase lasB can decrease host immune response through cleavage of respiratory tract surfactant proteins A and D and proteinase-activated receptor 2 into inactive forms.
Formal Description
Interaction-ID: 23348

gene/protein

lasB

decreases_quantity of

gene/protein

SFTPA1

Drugbank entries Show/Hide entries for lasB or SFTPA1
Comment P. aeruginosa elastase lasB can decrease host immune response through cleavage of respiratory tract surfactant proteins A and D and proteinase-activated receptor 2 into inactive forms.
Formal Description
Interaction-ID: 23349

gene/protein

lasB

decreases_quantity of

gene/protein

SFTPD

Drugbank entries Show/Hide entries for lasB or SFTPD
Comment P. aeruginosa elastase lasB can decrease host immune response through cleavage of respiratory tract surfactant proteins A and D and proteinase-activated receptor 2 into inactive forms.
Formal Description
Interaction-ID: 23350

gene/protein

lasB

decreases_activity of

gene/protein

F2RL1

Drugbank entries Show/Hide entries for lasB