General Information:

Id: 2,464
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Bleves S et al.(2010) Protein secretion systems in Pseudomonas aeruginosa: A wealth of pathogenic weapons. Int. J. Med. Microbiol. 300: 534-543 [PMID: 20947426]

Interaction Information:

Comment Except for the T4SS (type IV secretion system), all the other secretion machines described in Gram-negative bacteria have been identified in P. aeruginosa. Thanks to this secretion arsenal, P. aeruginosa is able to produce and release a very broad variety of exoproteins. In P. aeruginosa, 2 T1SS have been studied experimentally, the Apr system and the Has genes related system.
Formal Description
Interaction-ID: 22792

process

P. aeruginosa infection

increases_activity of

process

T1SS (Apr)

Apr genes T1SS system
Comment Except for the T4SS (type IV secretion system), all the other secretion machines described in Gram-negative bacteria have been identified in P. aeruginosa. Thanks to this secretion arsenal, P. aeruginosa is able to produce and release a very broad variety of exoproteins. In P. aeruginosa, 2 T1SS have been studied experimentally, the Apr system and the Has genes related system.
Formal Description
Interaction-ID: 22793

process

P. aeruginosa infection

increases_activity of

process

T1SS (Has)

Has genes T1SS system
Comment Except for the T4SS (type IV secretion system), all the other secretion machines described in Gram-negative bacteria have been identified in P. aeruginosa. Thanks to this secretion arsenal, P. aeruginosa is able to produce and release a very broad variety of exoproteins.
Formal Description
Interaction-ID: 22794

process

P. aeruginosa infection

increases_activity of

process

T2SS (Xcp)

Comment Except for the T4SS (type IV secretion system), all the other secretion machines described in Gram-negative bacteria have been identified in P. aeruginosa. Thanks to this secretion arsenal, P. aeruginosa is able to produce and release a very broad variety of exoproteins.
Formal Description
Interaction-ID: 22795

process

P. aeruginosa infection

increases_activity of

process

T3SS

Comment Except for the T4SS (type IV secretion system), all the other secretion machines described in Gram-negative bacteria have been identified in P. aeruginosa. Thanks to this secretion arsenal, P. aeruginosa is able to produce and release a very broad variety of exoproteins.
Formal Description
Interaction-ID: 22796

process

P. aeruginosa infection

increases_activity of

process

T5SS

Comment Two T1SS have been studied experimentally, the Apr system and the Has genes related system. The Apr system consists of AprD , AprE, and AprF and is involved in the extracellular secretion of the alkaline protease AprA and of AprX, a protein of unknown function. AprA is a recognized virulence factor involved in various Pseudomonas infections.
Formal Description
Interaction-ID: 22827

process

T1SS (Apr)

increases_transport of

gene/protein

aprA

into the extracellular medium
Comment Two T1SS have been studied experimentally, the Apr system and the Has genes related system. The Apr system consists of AprD , AprE, and AprF and is involved in the extracellular secretion of the alkaline protease AprA and of AprX, a protein of unknown function. AprA is a recognized virulence factor involved in various Pseudomonas infections.
Formal Description
Interaction-ID: 22828

process

T1SS (Apr)

increases_transport of

gene/protein

aprX

into the extracellular medium
Comment Two T1SS have been studied experimentally, the Apr system and the Has genes related system. The T1SS involved in utilization of iron requires the has genes. The secreted protein HasAp is a haemophore, which binds haem from haemoglobin. The HasAp-haem complex is addressed to the OM receptor, HasR, which further drives haem internalization.
Formal Description
Interaction-ID: 22832

gene/protein

hasAp

interacts (colocalizes) with

drug/chemical compound

Heme

Drugbank entries Show/Hide entries for
Comment Two T1SS have been studied experimentally, the Apr system and the Has genes related system. The T1SS involved in utilization of iron requires the has genes. The secreted protein HasAp is a haemophore, which binds haem from haemoglobin. The HasAp-haem complex is addressed to the OM receptor, HasR, which further drives haem internalization.
Formal Description
Interaction-ID: 22833

gene/protein

hasR

increases_transport of

drug/chemical compound

Heme

Drugbank entries Show/Hide entries for
Comment Two T1SS have been studied experimentally, the Apr system and the Has genes related system. The T1SS involved in utilization of iron requires the has genes. The secreted protein HasAp is a haemophore, which binds haem from haemoglobin. The HasAp-haem complex is addressed to the OM receptor, HasR, which further drives haem internalization.
Formal Description
Interaction-ID: 22838

process

T1SS (Has)

increases_transport of

gene/protein

hasAp

into the extracellular medium
Comment The HasAp-haem complex is addressed to the OM receptor, HasR, which further drives haem internalization.
Formal Description
Interaction-ID: 22906

gene/protein

hasAp

interacts (colocalizes) with

gene/protein

hasR

Comment The following secreted proteins are associated with T2SS (protein secretion by the type II secretion system), secretion type T2SS (Xcp).
Formal Description
Interaction-ID: 22943

process

T2SS (Xcp)

increases_transport of

gene/protein

lasB

into the extracellular medium
Drugbank entries Show/Hide entries for lasB
Comment The following secreted proteins are associated with T2SS (protein secretion by the type II secretion system), secretion type T2SS (Xcp).
Formal Description
Interaction-ID: 22950

process

T2SS (Xcp)

increases_transport of

gene/protein

lasA

into the extracellular medium
Comment The following secreted proteins are associated with T2SS (protein secretion by the type II secretion system), secretion type T2SS (Xcp).
Formal Description
Interaction-ID: 22952

process

T2SS (Xcp)

increases_transport of

gene/protein

plcH

into the extracellular medium
Comment The following secreted proteins are associated with T2SS (protein secretion by the type II secretion system), secretion type T2SS (Xcp).
Formal Description
Interaction-ID: 22953

process

T2SS (Xcp)

increases_transport of

gene/protein

plcN

into the extracellular medium
Comment The following secreted proteins are associated with T2SS (protein secretion by the type II secretion system), secretion type T2SS (Xcp).
Formal Description
Interaction-ID: 22966

process

T2SS (Xcp)

increases_transport of

gene/protein

plcB

into the extracellular medium
Comment The following secreted proteins are associated with T2SS (protein secretion by the type II secretion system), secretion type T2SS (Xcp).
Formal Description
Interaction-ID: 22968

process

T2SS (Xcp)

increases_transport of

gene/protein

cpbD

into the extracellular medium
Comment The following secreted proteins are associated with T2SS (protein secretion by the type II secretion system), secretion type T2SS (Xcp).
Formal Description
Interaction-ID: 22969

process

T2SS (Xcp)

increases_transport of

gene/protein

toxA

into the extracellular medium
Drugbank entries Show/Hide entries for toxA
Comment The following secreted proteins are associated with T2SS (protein secretion by the type II secretion system), secretion type T2SS (Xcp).
Formal Description
Interaction-ID: 22972

process

T2SS (Xcp)

increases_transport of

gene/protein

PA0572

into the extracellular medium
Comment The following secreted proteins are associated with T2SS (protein secretion by the type II secretion system), secretion type T2SS (Xcp).
Formal Description
Interaction-ID: 22976

process

T2SS (Xcp)

increases_transport of

gene/protein

prpL

into the extracellular medium
Comment The following secreted proteins are associated with T2SS (protein secretion by the type II secretion system), secretion type T2SS (Xcp).
Formal Description
Interaction-ID: 22979

process

T2SS (Xcp)

increases_transport of

gene/protein

lipA

into the extracellular medium
Drugbank entries Show/Hide entries for lipA
Comment The following secreted proteins are associated with T2SS (protein secretion by the type II secretion system), secretion type T2SS (Xcp).
Formal Description
Interaction-ID: 22981

process

T2SS (Xcp)

increases_transport of

gene/protein

lipC

into the extracellular medium
Comment The following secreted proteins are associated with T2SS (protein secretion by the type II secretion system), secretion type T2SS (Xcp).
Formal Description
Interaction-ID: 22983

process

T2SS (Xcp)

increases_transport of

gene/protein

phoA

into the extracellular medium
Drugbank entries Show/Hide entries for phoA
Comment The following secreted proteins are associated with T2SS (protein secretion by the type II secretion system), secretion type T2SS (Xcp).
Formal Description
Interaction-ID: 22984

process

T2SS (Xcp)

increases_transport of

gene/protein

paaP

into the extracellular medium
Comment The following secreted proteins are associated with T3SS (protein secretion by the type III secretion system). Strains of P. aeruginosa have different combinations of genes encoding T3SS effectors and can be divided into 2 groups. The cytotoxic strains possess exoU, exoT, and sometimes exoY (e.g. strain PA103 or PA14), whereas invasive isolates possess exoS, exoT, and often exoY (e.g. strain PAO1 or PAK).
Formal Description
Interaction-ID: 23018

process

T3SS

increases_transport of

gene/protein

exoU

into the host cell
Comment The following secreted proteins are associated with T3SS (protein secretion by the type III secretion system). Strains of P. aeruginosa have different combinations of genes encoding T3SS effectors and can be divided into 2 groups. The cytotoxic strains possess exoU, exoT, and sometimes exoY (e.g. strain PA103 or PA14), whereas invasive isolates possess exoS, exoT, and often exoY (e.g. strain PAO1 or PAK).
Formal Description
Interaction-ID: 23033

process

T3SS

increases_transport of

gene/protein

exoT

into the host cell
Comment The following secreted proteins are associated with T3SS (protein secretion by the type III secretion system). Strains of P. aeruginosa have different combinations of genes encoding T3SS effectors and can be divided into 2 groups. The cytotoxic strains possess exoU, exoT, and sometimes exoY (e.g. strain PA103 or PA14), whereas invasive isolates possess exoS, exoT, and often exoY (e.g. strain PAO1 or PAK).
Formal Description
Interaction-ID: 23034

process

T3SS

increases_transport of

gene/protein

exoY

into the host cell
Comment The following secreted proteins are associated with T3SS (protein secretion by the type III secretion system). Strains of P. aeruginosa have different combinations of genes encoding T3SS effectors and can be divided into 2 groups. The cytotoxic strains possess exoU, exoT, and sometimes exoY (e.g. strain PA103 or PA14), whereas invasive isolates possess exoS, exoT, and often exoY (e.g. strain PAO1 or PAK).
Formal Description
Interaction-ID: 23035

process

T3SS

increases_transport of

gene/protein

exoS

into the host cell
Comment The following secreted proteins are associated with T5SS (protein secretion by the type V secretion system). Two subtypes of T5SS exist in Gram-negative bacteria: the autotransporters (AT or T5aSS and T5cSS) and the 2-partner secretion (TPS or T5bSS). EstA is the only characterized autotransporter in P. aeruginosa.
Formal Description
Interaction-ID: 23057

process

T5aSS

increases_transport of

gene/protein

estA

into the extracellular medium
Drugbank entries Show/Hide entries for estA
Comment EstA is involved in the production of rhamnolipids.
Formal Description
Interaction-ID: 23081

gene/protein

estA

affects_quantity of

cellular component

rhamnolipid

Drugbank entries Show/Hide entries for estA
Comment The following secreted proteins are associated with T5SS (protein secretion by the type V secretion system). Two subtypes of T5SS exist in Gram-negative bacteria: the autotransporters (AT or T5aSS and T5cSS) and the 2-partner secretion (TPS (two-partner secretion) or T5bSS).
Formal Description
Interaction-ID: 23084

process

T5bSS

increases_transport of

gene/protein

lepA

into the extracellular medium
Comment LepA is a protease that activates the critical transcription factor NF-kappaB for host inflammatory and immune responses through digestion of human specific receptors (PAR-1, -2, or -4).
Formal Description
Interaction-ID: 23196

gene/protein

lepA

increases_activity of

gene/protein

F2R

Drugbank entries Show/Hide entries for F2R
Comment LepA is a protease that activates the critical transcription factor NF-kappaB for host inflammatory and immune responses through digestion of human specific receptors (PAR-1, -2, or -4).
Formal Description
Interaction-ID: 23197

gene/protein

lepA

increases_activity of

gene/protein

F2RL1

Comment LepA is a protease that activates the critical transcription factor NF-kappaB for host inflammatory and immune responses through digestion of human specific receptors (PAR-1, -2, or -4).
Formal Description
Interaction-ID: 23207

gene/protein

lepA

increases_activity of

gene/protein

F2RL3

Comment The following secreted proteins are associated with T5SS (protein secretion by the type V secretion system). Two subtypes of T5SS exist in Gram-negative bacteria: the autotransporters (AT or T5aSS and T5cSS) and the 2-partner secretion (TPS (two-partner secretion) or T5bSS). The TpsA6/CupB5 protein is a hemagglutinin-like protein that may be interwoven with the CupB fimbriae.
Formal Description
Interaction-ID: 23209

process

T5bSS

increases_transport of

gene/protein

cupB5

Comment If the P-usher (POTRA-containing usher)/CupB3 lacks its POTRA, TpsA/CupB5 is misfolded. The misfolded TpsA/CupB5 blocks the CupB3 channel and prevents further assembly of CupB fimbriae.
Formal Description
Interaction-ID: 23216

gene/protein

cupB5

increases_activity of

process

CupB fimbriae assembly

Comment LepA is a protease that activates the critical transcription factor NF-kappaB for host inflammatory and immune responses through digestion of human specific receptors (PAR-1, -2, or -4).
Formal Description
Interaction-ID: 23691

increases_activity of

Comment LepA is a protease that activates the critical transcription factor NF-kappaB for host inflammatory and immune responses through digestion of human specific receptors (PAR-1, -2, or -4).
Formal Description
Interaction-ID: 23694

increases_activity of

process

immune response

Comment LepA is a protease that activates the critical transcription factor NF-kappaB for host inflammatory and immune responses through digestion of human specific receptors (PAR-1, -2, or -4).
Formal Description
Interaction-ID: 23696

gene/protein

F2R

increases_activity of

Drugbank entries Show/Hide entries for F2R
Comment LepA is a protease that activates the critical transcription factor NF-kappaB for host inflammatory and immune responses through digestion of human specific receptors (PAR-1, -2, or -4).
Formal Description
Interaction-ID: 23697

gene/protein

F2RL1

increases_activity of

Comment LepA is a protease that activates the critical transcription factor NF-kappaB for host inflammatory and immune responses through digestion of human specific receptors (PAR-1, -2, or -4).
Formal Description
Interaction-ID: 23698

gene/protein

F2RL3

increases_activity of

Comment The secretion of Hcp1 is so far the only example of a T6SS substrate in P. aeruginosa, and the Hcp1 protein can be detected in the sputum of cystic fibrosis patients.
Formal Description
Interaction-ID: 24062

process

T6SS-HSI-1

increases_transport of

gene/protein

hcp1

into the host cell / into the extracellular medium; in patients with CF
Comment The secretion of Hcp1 is so far the only example of a T6SS substrate of the HSI-1 machinery in P. aeruginosa, and the Hcp1 protein can be detected in the sputum of cystic fibrosis patients.
Formal Description
Interaction-ID: 24081

process

P. aeruginosa infection, chronic

increases_activity of

process

T6SS-HSI-1

Comment Animal and plant infection studies reveal that both T6SS-HSI-II and -III play important roles in P. aeruginosa virulence.
Formal Description
Interaction-ID: 24082

process

P. aeruginosa infection

increases_activity of

process

T6SS-HSI-2

Comment Animal and plant infection studies reveal that both T6SS-HSI-II and -III play important roles in P. aeruginosa virulence.
Formal Description
Interaction-ID: 24083

process

P. aeruginosa infection

increases_activity of

process

T6SS-HSI-3

Comment Except for the T4SS (type IV secretion system), all the other secretion machines described in Gram-negative bacteria have been identified in P. aeruginosa. Thanks to this secretion arsenal, P. aeruginosa is able to produce and release a very broad variety of exoproteins.
Formal Description
Interaction-ID: 26940

process

P. aeruginosa infection

increases_activity of

process

T2SS (Hxc)

Comment The TpsB4 transporter (PA4540) named LepB is required for the secretion of the TpsA4 (PA4541) protein, LepA.
Formal Description
Interaction-ID: 27001

gene/protein

lepB

increases_transport of

gene/protein

lepA

Drugbank entries Show/Hide entries for lepB
Comment The following secreted proteins are associated with T5SS (protein secretion by the type V secretion system). Two subtypes of T5SS exist in Gram-negative bacteria: the autotransporters (AT or T5aSS and T5cSS) and the 2-partner secretion (TPS or T5bSS). EstA is the only characterized autotransporter in P. aeruginosa.
Formal Description
Interaction-ID: 28026

process

T5aSS

is_part_of

process

T5SS

Comment The following secreted proteins are associated with T5SS (protein secretion by the type V secretion system). Two subtypes of T5SS exist in Gram-negative bacteria: the autotransporters (AT or T5aSS and T5cSS) and the 2-partner secretion (TPS or T5bSS). EstA is the only characterized autotransporter in P. aeruginosa.
Formal Description
Interaction-ID: 28037

process

T5bSS

is_part_of

process

T5SS