General Information:

Id: 2,400
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0000567 HeLa cell, infected with P. aeruginosa strain PAK
article
Reference: Jia J et al.(2003) c-Jun NH2-terminal kinase-mediated signaling is essential for Pseudomonas aeruginosa ExoS-induced apoptosis. Infect. Immun. 71: 3361-3370 [PMID: 12761120]

Interaction Information:

Comment ExoS activates JNK phosphorylation and blocks p38 and ERK1/2 phosphorylation in HeLa cells.
Formal Description
Interaction-ID: 21367

gene/protein

exoS

increases_activity of

gene/protein

MAPK8

at 2-4 hours postinfection
Drugbank entries Show/Hide entries for MAPK8
Comment ExoS activates JNK phosphorylation and blocks p38 and ERK1/2 phosphorylation in HeLa cells.
Formal Description
Interaction-ID: 21368

gene/protein

exoS

increases_phosphorylation of

gene/protein

MAPK8

at 2-4 hours postinfection
Drugbank entries Show/Hide entries for MAPK8
Comment ExoS activates JNK phosphorylation and blocks p38 and ERK1/2 phosphorylation in HeLa cells.
Formal Description
Interaction-ID: 21369

gene/protein

exoS

increases_activity of

gene/protein

MAPK9

at 2-4 hours postinfection
Drugbank entries Show/Hide entries for MAPK9
Comment ExoS activates JNK phosphorylation and blocks p38 and ERK1/2 phosphorylation in HeLa cells.
Formal Description
Interaction-ID: 21370

gene/protein

exoS

increases_phosphorylation of

gene/protein

MAPK9

at 2-4 hours postinfection
Drugbank entries Show/Hide entries for MAPK9
Comment ExoS activates JNK phosphorylation and blocks p38 and ERK1/2 phosphorylation in HeLa cells.
Formal Description
Interaction-ID: 21371

gene/protein

exoS

decreases_activity of

gene/protein

p38 MAPK

at 2-4 hours postinfection
Comment ExoS activates JNK phosphorylation and blocks p38 and ERK1/2 phosphorylation in HeLa cells.
Formal Description
Interaction-ID: 21372

gene/protein

exoS

decreases_phosphorylation of

gene/protein

p38 MAPK

at 2-4 hours postinfection
Comment ExoS activates JNK phosphorylation and blocks p38 and ERK1/2 phosphorylation in HeLa cells.
Formal Description
Interaction-ID: 21373

gene/protein

exoS

decreases_activity of

gene/protein

MAPK3

at 2-4 hours postinfection
Drugbank entries Show/Hide entries for MAPK3
Comment ExoS activates JNK phosphorylation and blocks p38 and ERK1/2 phosphorylation in HeLa cells.
Formal Description
Interaction-ID: 21374

gene/protein

exoS

decreases_phosphorylation of

gene/protein

MAPK3

at 2-4 hours postinfection
Drugbank entries Show/Hide entries for MAPK3
Comment ExoS activates JNK phosphorylation and blocks p38 and ERK1/2 phosphorylation in HeLa cells.
Formal Description
Interaction-ID: 21375

gene/protein

exoS

decreases_activity of

gene/protein

MAPK1

at 2-4 hours postinfection
Drugbank entries Show/Hide entries for MAPK1
Comment ExoS activates JNK phosphorylation and blocks p38 and ERK1/2 phosphorylation in HeLa cells.
Formal Description
Interaction-ID: 21376

gene/protein

exoS

decreases_phosphorylation of

gene/protein

MAPK1

at 2-4 hours postinfection
Drugbank entries Show/Hide entries for MAPK1
Comment JNK-mediated signaling is essential for the ExoS-induced apoptosis.
Formal Description
Interaction-ID: 21378

gene/protein

exoS

increases_activity of

process

JNK cascade

Comment ExoS activates proapoptotic pathways through activation of JNK1/2 leading ultimately to cytochrome c release and activation of caspases.
Formal Description
Interaction-ID: 21380

gene/protein

exoS

increases_activity of