General Information:

Id: 2,395 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0000944 NIH-3T3 cell; BTO:0000837 MDCK cell, infected with Y. pseudotuberculosis expressing ExoS
article
Reference: Jansson AL et al.(2006) Exoenzyme S of Pseudomonas aeruginosa is not able to induce apoptosis when cells express activated proteins, such as Ras or protein kinase B/Akt. Cell. Microbiol. 8: 815-822 [PMID: 16611230]

Interaction Information:

Comment The observed cell death induced by the ExoS toxin correlates with both a decrease in phosphorylated FOXO3a protein and an increase in caspase-3 activity.
Formal Description
Interaction-ID: 21279

gene/protein

exoS

decreases_phosphorylation of

gene/protein

FOXO3