General Information:

Id: 2,380 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0000567 HeLa cell, infected with P. aeruginosa strain PAK
Reference: Jia J et al.(2006) Expression of Pseudomonas aeruginosa toxin ExoS effectively induces apoptosis in host cells. Infect. Immun. 74: 6557-6570 [PMID: 16966406]

Interaction Information:

Comment Transient expression of exoS in HeLa cells is sufficient to elicit apoptosis, and this is dependent on ADPRT (ADP-ribosylation activity) but not on GAP (GTPase-activating domain) activity of the ExoS. EGFP-ExoS expression led to gradually enhanced caspase-3 activation, resulting in activated caspase-3.
Formal Description
Interaction-ID: 20900



increases_activity of



Drugbank entries Show/Hide entries for CASP3