General Information:

Id: 2,370 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
P. aeruginosa strain PAO1
article
Reference: Kang Y et al.(2008) The Pseudomonas aeruginosa PsrA responds to long-chain fatty acid signals to regulate the fadBA5 beta-oxidation operon. Microbiology (Reading 154: 1584-1598 [PMID: 18524913]

Interaction Information:

Comment Long-chain fatty acids (LCFAs) are the inducer of fadBA5, and bind to PsrA to derepress the fadBA5 operon in P. aeruginosa. The binding of PsrA to the fadBA5 promoter region is disrupted by specific LCFAs (C(18:1)(Delta9), C(16:0), C(14:0) and, to a lesser extent, C(12:0)), but not by other medium- or short-chain fatty acids.
Formal Description
Interaction-ID: 20807

drug/chemical compound

Long-chain fatty acid

decreases_activity of

gene/protein

psrA

reaction is specific for LCFAs (C(18:1)(Delta9), C(16:0), C(14:0) and, to a lesser extent, C(12:0)), but not by other medium- or short-chain fatty acids