General Information:

Id: 2,363
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
P. aeruginosa strain PAO1
article
Reference: Kang Y et al.(2009) The long-chain fatty acid sensor, PsrA, modulates the expression of rpoS and the type III secretion exsCEBA operon in Pseudomonas aeruginosa. Mol. Microbiol. 73: 120-136 [PMID: 19508282]

Interaction Information:

Comment PsrA and long-chain fatty acid (LCFA) signals have recently been shown to act as repressor-inducer partners to regulate genes for fatty acid degradation (Fad). The LCFA, oleate (C18:1delta9 ), down regulates rpoS and TTSS genes shown by microarray analyses.
Formal Description
Interaction-ID: 20688

drug/chemical compound

Long-chain fatty acid

decreases_expression of

gene/protein

rpoS

LCFA used in this exp. was oleate, in KEGG C00712
Comment PsrA and long-chain fatty acid (LCFA) signals have recently been shown to act as repressor-inducer partners to regulate genes for fatty acid degradation (Fad). The LCFA, oleate (C18:1delta9 ), down regulates rpoS and TTSS genes shown by microarray analyses.
Formal Description
Interaction-ID: 20740

drug/chemical compound

Long-chain fatty acid

decreases_expression of

gene/protein

exsC

LCFA used in this exp. was oleate, in KEGG C00712
Comment PsrA and long-chain fatty acid (LCFA) signals have recently been shown to act as repressor-inducer partners to regulate genes for fatty acid degradation (Fad). The LCFA, oleate (C18:1delta9 ), down regulates rpoS and TTSS genes shown by microarray analyses.
Formal Description
Interaction-ID: 20741

drug/chemical compound

Long-chain fatty acid

decreases_expression of

gene/protein

exsE

LCFA used in this exp. was oleate, in KEGG C00712
Comment PsrA and long-chain fatty acid (LCFA) signals have recently been shown to act as repressor-inducer partners to regulate genes for fatty acid degradation (Fad). The LCFA, oleate (C18:1delta9 ), down regulates rpoS and TTSS genes shown by microarray analyses.
Formal Description
Interaction-ID: 20743

drug/chemical compound

Long-chain fatty acid

decreases_expression of

gene/protein

exsB

LCFA used in this exp. was oleate, in KEGG C00712
Comment PsrA and long-chain fatty acid (LCFA) signals have recently been shown to act as repressor-inducer partners to regulate genes for fatty acid degradation (Fad). The LCFA, oleate (C18:1delta9 ), down regulates rpoS and TTSS genes shown by microarray analyses.
Formal Description
Interaction-ID: 20744

drug/chemical compound

Long-chain fatty acid

decreases_expression of

gene/protein

exoS

LCFA used in this exp. was oleate, in KEGG C00712
Comment Long-chain fatty acid (LCFA) influences the conformation of PsrA upon binding, such that the PsrA-LCFA complex is unable to act as a repressor for PpsrA nor as an activator for PrpoS and PexsC.
Formal Description
Interaction-ID: 20761

drug/chemical compound

Long-chain fatty acid

affects_folding of

gene/protein

psrA

LCFA used in this exp. was oleate, in KEGG C00712
Comment Long-chain fatty acid (LCFA) decreased rpoS and exsC expression, resulting in increased N-(butyryl)-l-homoserine-lactone quorum sensing signal and decreased ExoS/T production respectively.
Formal Description
Interaction-ID: 20770

drug/chemical compound

Long-chain fatty acid

increases_quantity of

drug/chemical compound

N-Butyryl-HSL

LCFA used in this exp. was oleate, in KEGG C00712
Comment Long-chain fatty acid (LCFA) decreased rpoS and exsC expression, resulting in increased N-(butyryl)-l-homoserine-lactone quorum sensing signal and decreased ExoS/T production respectively.
Formal Description
Interaction-ID: 20771

drug/chemical compound

Long-chain fatty acid

affects_activity of

process

Acyl-HSL quorum sensing

LCFA used in this exp. was oleate, in KEGG C00712
Comment Long-chain fatty acid (LCFA) decreased the expression of ExoS and ExoT in all growth phases from ML (mid-log) to ES (early-stationary).
Formal Description
Interaction-ID: 20777

drug/chemical compound

Long-chain fatty acid

decreases_expression of

gene/protein

exoT

LCFA used in this exp. was oleate, in KEGG C00712
Comment Down-regulation of rpoS and TTSS (e.g. exoS and exoT) in the presence of long-chain fatty acid (LCFA) significantly affects virulence behavior of P. aeruginosa.
Formal Description
Interaction-ID: 20781

drug/chemical compound

Long-chain fatty acid

affects_activity of

process

P. aeruginosa infection

Comment The down regulation of ExoS and ExoT was confirmed by western blot analysis from ML (mid-log) to ES (early-stationary) growth phases in the presence of LCFA.
Formal Description
Interaction-ID: 20787

drug/chemical compound

Long-chain fatty acid

decreases_quantity of

gene/protein

exoS

LCFA used in this exp. was oleate, in KEGG C00712
Comment The down regulation of ExoS and ExoT was confirmed by western blot analysis from ML (mid-log) to ES (early-stationary) growth phases in the presence of LCFA.
Formal Description
Interaction-ID: 20788

drug/chemical compound

Long-chain fatty acid

decreases_quantity of

gene/protein

exoT

LCFA used in this exp. was oleate, in KEGG C00712