General Information:

Id: 2,359
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
article/cited
Reference: Kang Y et al.(2009) The long-chain fatty acid sensor, PsrA, modulates the expression of rpoS and the type III secretion exsCEBA operon in Pseudomonas aeruginosa. Mol. Microbiol. 73: 120-136 [PMID: 19508282]

Interaction Information:

Comment The Pseudomonas aeruginosa PsrA autorepressor has dual roles as a repressor of the fadBA5beta-oxidation operon and an activator of the stationary-phase sigma factor rpoS and exsCEBA operon of the type III secretion system (TTSS). (cited information)
Formal Description
Interaction-ID: 20627

gene/protein

psrA

increases_expression of

gene/protein

exsC

Comment The Pseudomonas aeruginosa PsrA autorepressor has dual roles as a repressor of the fadBA5beta-oxidation operon and an activator of the stationary-phase sigma factor rpoS and exsCEBA operon of the type III secretion system (TTSS). (cited information)
Formal Description
Interaction-ID: 20640

gene/protein

psrA

increases_expression of

gene/protein

exsE

Comment The Pseudomonas aeruginosa PsrA autorepressor has dual roles as a repressor of the fadBA5beta-oxidation operon and an activator of the stationary-phase sigma factor rpoS and exsCEBA operon of the type III secretion system (TTSS). (cited information)
Formal Description
Interaction-ID: 20641

gene/protein

psrA

increases_expression of

gene/protein

exsB

Comment The Pseudomonas aeruginosa PsrA autorepressor has dual roles as a repressor of the fadBA5beta-oxidation operon and an activator of the stationary-phase sigma factor rpoS and exsCEBA operon of the type III secretion system (TTSS). (cited information)
Formal Description
Interaction-ID: 20642

gene/protein

psrA

increases_expression of

gene/protein

exsA

Comment The Pseudomonas aeruginosa PsrA autorepressor has dual roles as a repressor of the fadBA5beta-oxidation operon and an activator of the stationary-phase sigma factor rpoS and exsCEBA operon of the type III secretion system (TTSS). (cited information)
Formal Description
Interaction-ID: 20643

gene/protein

psrA

increases_expression of

gene/protein

rpoS

Comment The Pseudomonas aeruginosa PsrA autorepressor has dual roles as a repressor of the fadBA5beta-oxidation operon and an activator of the stationary-phase sigma factor rpoS and exsCEBA operon of the type III secretion system (TTSS). (cited information)
Formal Description
Interaction-ID: 20644

gene/protein

psrA

decreases_expression of

gene/protein

psrA

Comment The Pseudomonas aeruginosa PsrA autorepressor has dual roles as a repressor of the fadBA5beta-oxidation operon and an activator of the stationary-phase sigma factor rpoS and exsCEBA operon of the type III secretion system (TTSS). (cited information)
Formal Description
Interaction-ID: 20654

gene/protein

psrA

decreases_expression of

gene/protein

foaB

Comment The Pseudomonas aeruginosa PsrA autorepressor has dual roles as a repressor of the fadBA5beta-oxidation operon and an activator of the stationary-phase sigma factor rpoS and exsCEBA operon of the type III secretion system (TTSS). (cited information)
Formal Description
Interaction-ID: 20664

gene/protein

psrA

decreases_expression of

gene/protein

faoA

Comment It was demonstrated that PsrA directly repressed specific Fad genes (fadBA5), while the binding of LCFAs (long-chain fatty acids) to PsrA inhibited repression. (cited information)
Formal Description
Interaction-ID: 20675

drug/chemical compound

Long-chain fatty acid

decreases_activity of

gene/protein

psrA

Comment Microarray data from an earlier study indicated that PsrA was induced (5.5-fold) in vivo during P. aeruginosa infection of the cystic fibrosis lung versus in vitro growth, suggesting the presence of sufficient LCFA in vivo for PsrA induction. (cited information)
Formal Description
Interaction-ID: 20784

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

psrA

in CF patients