General Information:

Id: 2,354
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
P. aeruginosa strain PAO1
article
Reference: Bleves S et al.(2005) Quorum sensing negatively controls type III secretion regulon expression in Pseudomonas aeruginosa PAO1. J. Bacteriol. 187: 3898-3902 [PMID: 15901720]

Interaction Information:

Comment The expression analysis of effector genes of strain PAO1, namely, exoS, -T, and -Y genes, showed that they were all strictly regulated by ExsA in a Ca2+-dependent manner.
Formal Description
Interaction-ID: 20591

gene/protein

exsA

increases_expression of

gene/protein

exoS

Comment The expression analysis of effector genes of strain PAO1, namely, exoS, -T, and -Y genes, showed that they were all strictly regulated by ExsA in a Ca2+-dependent manner.
Formal Description
Interaction-ID: 20592

gene/protein

exsA

increases_expression of

gene/protein

exoT

Comment The expression analysis of effector genes of strain PAO1, namely, exoS, -T, and -Y genes, showed that they were all strictly regulated by ExsA in a Ca2+-dependent manner.
Formal Description
Interaction-ID: 20593

gene/protein

exsA

increases_expression of

gene/protein

exoY

Comment In the lasR mutant, expression levels of T3S-secretion-operon, T3S-translocation-operon), and T3S-plug-operon were fairly similar to expression levels obtained in the PAO1 strain.
Formal Description
Interaction-ID: 28128

process

LasR/I-3OC12-(HSL)-system

NOT affects_expression of

complex/PPI

T3SS complex

Comment In the rhlI mutant, expression levels of T3S-secretion-operon, T3S-translocation-operon), and T3S-plug-operon were up-regulated. Addition of C4-HSL in the rhlI mutant culture medium reduced activities of promoters pD, pS, pT, and pY to PAO1 levels.
Formal Description
Interaction-ID: 28130

process

RhlR/I-C4-(HSL)-system

decreases_expression of

complex/PPI

T3SS complex

Comment ExoS secretion is advanced during the growth of an rhlI mutant. Moreover, the addition of exogenous C4-HSL to the culture medium of a rhlI mutant delayed ExoS secretion and thus mimicked the behavior observed in PAO1.
Formal Description
Interaction-ID: 28132

process

RhlR/I-C4-(HSL)-system

decreases transport of

gene/protein

exoS

Comment exsCBA is the only T3S operon that is not controlled by a QS component, since promoter pC activity is affected by neither a lasR nor a rhlI mutation.
Formal Description
Interaction-ID: 28134

process

LasR/I-3OC12-(HSL)-system

NOT affects_expression of

gene/protein

exsA

Comment exsCBA is the only T3S operon that is not controlled by a QS component, since promoter pC activity is affected by neither a lasR nor a rhlI mutation.
Formal Description
Interaction-ID: 28143

process

RhlR/I-C4-(HSL)-system

NOT affects_expression of

gene/protein

exsA