General Information:

Id: 2,336 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Hauser AR(2009) The type III secretion system of Pseudomonas aeruginosa: infection by injection. Nat. Rev. Microbiol. 7: 654-665 [PMID: 19680249]

Interaction Information:

Comment ExoU has phospholipase A2 (PLA2) activity. The lipase activity of ExoU has a broad range of substrates, including phospholipids, lysophospholipids, and neutral lipids.
Formal Description
Interaction-ID: 20394

gene/protein

exoU

decreases_quantity of

drug/chemical compound

Phospholipid

by degradation
Comment ExoU has phospholipase A2 (PLA2) activity. The lipase activity of ExoU has a broad range of substrates, including phospholipids, lysophospholipids, and neutral lipids.
Formal Description
Interaction-ID: 20403

gene/protein

exoU

decreases_quantity of

drug/chemical compound

Lysophospholipid

by degradation
Comment ExoU requires the eukaryotic cofactor SOD1 for activation.
Formal Description
Interaction-ID: 20586

gene/protein

SOD1

increases_activity of

gene/protein

exoU

Drugbank entries Show/Hide entries for SOD1