General Information:

Id: 2,336 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Hauser AR(2009) The type III secretion system of Pseudomonas aeruginosa: infection by injection. Nat. Rev. Microbiol. 7: 654-665 [PMID: 19680249]

Interaction Information:

Comment The GAP (GTPase activating protein) and ADPRT (adenosine diphosphate ribosyl transferase activity) activities of ExoT work together to alter the actin cytoskeleton and to inhibit cell migration, adhesion, and proliferation. The net effect of these activities is to block phagocytosis and disrupt epithelial barriers to facilitate bacterial dissemination.
Formal Description
Interaction-ID: 20385

gene/protein

exoT

decreases_activity of

process

phagocytosis