General Information:

Id: 2,336 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Hauser AR(2009) The type III secretion system of Pseudomonas aeruginosa: infection by injection. Nat. Rev. Microbiol. 7: 654-665 [PMID: 19680249]

Interaction Information:

Comment Similar to ExoS, ExoT residues 78-235 contain GAP activity towards Rac, Rho, and Cdc42. This activity appears to be very similar to that of the N-terminus of ExoS and causes reversible disruption of the actin cytoskeleton.
Formal Description
Interaction-ID: 20379

gene/protein

exoT

decreases_activity of

gene/protein

RAC1

Drugbank entries Show/Hide entries for RAC1
Comment Similar to ExoS, ExoT residues 78-235 contain GAP activity towards Rac, Rho, and Cdc42. This activity appears to be very similar to that of the N-terminus of ExoS and causes reversible disruption of the actin cytoskeleton.
Formal Description
Interaction-ID: 20380

gene/protein

exoT

decreases_activity of

gene/protein

RHOA

Drugbank entries Show/Hide entries for RHOA
Comment Similar to ExoS, ExoT residues 78-235 contain GAP activity towards Rac, Rho, and Cdc42. This activity appears to be very similar to that of the N-terminus of ExoS and causes reversible disruption of the actin cytoskeleton.
Formal Description
Interaction-ID: 20381

gene/protein

exoT

decreases_activity of

gene/protein

CDC42

Drugbank entries Show/Hide entries for CDC42
Comment Similar to ExoS, ExoT residues 78-235 contain GAP activity towards Rac, Rho, and Cdc42. This activity appears to be very similar to that of the N-terminus of ExoS and causes reversible disruption of the actin cytoskeleton.
Formal Description
Interaction-ID: 20382

gene/protein

exoT

decreases_activity of

Comment ExoT ADP-ribosylates a distinct and limited number of host proteins, in particular the CT10-regulator of kinase (Crk)-I and Crk-II, adaptor proteins.
Formal Description
Interaction-ID: 20384

gene/protein

exoT

affects_activity of

gene/protein

CRK

Comment The GAP (GTPase activating protein) and ADPRT (adenosine diphosphate ribosyl transferase activity) activities of ExoT work together to alter the actin cytoskeleton and to inhibit cell migration, adhesion, and proliferation. The net effect of these activities is to block phagocytosis and disrupt epithelial barriers to facilitate bacterial dissemination.
Formal Description
Interaction-ID: 20385

gene/protein

exoT

decreases_activity of

process

phagocytosis

Comment ExoT forms a complex with its substrate Crk and a Crk ligand, the E3 ubiquitin ligase Cbl-b, leading to polyubiquitination of ExoT by Cbl-b and subsequent proteasomal degradation.
Formal Description
Interaction-ID: 20386

gene/protein

exoT

interacts (colocalizes) with

gene/protein

CRK

Comment ExoT forms a complex with its substrate Crk and a Crk ligand, the E3 ubiquitin ligase Cbl-b, leading to polyubiquitination of ExoT by Cbl-b and subsequent proteasomal degradation.
Formal Description
Interaction-ID: 20387

gene/protein

exoT

interacts (colocalizes) with

gene/protein

CBLB

Comment ExoT forms a complex with its substrate Crk and a Crk ligand, the E3 ubiquitin ligase Cbl-b, leading to polyubiquitination of ExoT by Cbl-b and subsequent proteasomal degradation.
Formal Description
Interaction-ID: 20388

gene/protein

CBLB

increases_ubiquitination/sumoylation of

gene/protein

exoT

Comment ExoT ADP-ribosylates a distinct and limited number of host proteins, in particular the CT10-regulator of kinase (Crk)-I and Crk-II, adaptor proteins.
Formal Description
Interaction-ID: 23445

gene/protein

exoT

increases_activity of