General Information:

Id: 2,336 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
Reference: Hauser AR(2009) The type III secretion system of Pseudomonas aeruginosa: infection by injection. Nat. Rev. Microbiol. 7: 654-665 [PMID: 19680249]

Interaction Information:

Comment ExoS is a GTPase activating protein. Residues 96-233 of ExoS form a GAP domain that targets RhoA, Rac1, and Cdc42, small GTPases that maintain the organization of the actin cytoskeleton. These regulatory GTPases normally switch between an active GTP-bound form and an inactive GDP-bound form, but the ExoS GAP domain biases the switch towards the ADP-bound inactive form, leading to disruption of the actin cytoskeleton.
Formal Description
Interaction-ID: 20370



decreases_activity of