General Information:

Id: 2,299
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0005002 pulmonary microvascular endothelial cell, infected with P. aeruginosa strain 388
article
Reference: Sayner SL et al.(2011) Filamin A is a phosphorylation target of membrane but not cytosolic adenylyl cyclase activity. Am. J. Physiol. Lung Cell Mol. Physiol. 301: L117-L124 [PMID: 21478251]

Interaction Information:

Comment cAMP signals are strictly compartmentalized. cAMP emanating from transmembrane ACs (adenylyl cyclase) activates barrier-enhancing targets. Isoproterenol stimulation of transmembrane AC (AC6) activity leads to an increase in filamin A phosphorylation at serine 2152 without changing total filamin A levels.
Formal Description
Interaction-ID: 19663

gene/protein

ADCY6

increases_quantity of

drug/chemical compound

cAMP

in transmembrane compartment, subplasma membrane
Drugbank entries Show/Hide entries for cAMP
Comment cAMP signals are strictly compartmentalized. cAMP emanating from transmembrane ACs (adenylyl cyclase) activates barrier-enhancing targets. Isoproterenol stimulation of transmembrane AC (AC6) activity leads to an increase in filamin A phosphorylation at serine 2152 without changing total filamin A levels.
Formal Description
Interaction-ID: 19673

gene/protein

ADCY6

increases_activity of

Comment cAMP signals are strictly compartmentalized. cAMP emanating from transmembrane ACs (adenylyl cyclase) activates barrier-enhancing targets. Isoproterenol stimulation of transmembrane AC (AC6) activity leads to an increase in filamin A phosphorylation at serine 2152 without changing total filamin A levels.
Formal Description
Interaction-ID: 19678

gene/protein

ADCY6

increases_activity of

gene/protein

FLNA

Comment cAMP signals are strictly compartmentalized. cAMP emanating from soluble ACs (adenylyl cyclase) activates barrier-disrupting targets, such as tau. P. aeruginosa secretes the cytosolic exotoxin, ExoY, a adenylyl cyclase, into PMVECs (pulmonary microvascular endothelial cells). ExoY utilizes a eukaryotic factor to stimulate AC activity, generating cAMP in the cytosolic compartment sufficient to induce endothelial cell gaps.
Formal Description
Interaction-ID: 19681

gene/protein

exoY

increases_quantity of

drug/chemical compound

cAMP

in cytosolic compartment
Drugbank entries Show/Hide entries for cAMP
Comment cAMP signals are strictly compartmentalized. cAMP emanating from soluble ACs (adenylyl cyclase) activates barrier-disrupting targets, such as tau. P. aeruginosa secretes the cytosolic exotoxin, ExoY, a adenylyl cyclase, into PMVECs (pulmonary microvascular endothelial cells). ExoY utilizes a eukaryotic factor to stimulate AC activity, generating cAMP in the cytosolic compartment sufficient to induce endothelial cell gaps.
Formal Description
Interaction-ID: 19684

gene/protein

exoY

decreases_activity of

Comment cAMP signals are strictly compartmentalized. cAMP emanating from soluble ACs (adenylyl cyclase) activates barrier-disrupting targets, such as tau. P. aeruginosa secretes the cytosolic exotoxin, ExoY, a adenylyl cyclase, into PMVECs (pulmonary microvascular endothelial cells). ExoY utilizes a eukaryotic factor to stimulate AC activity, generating cAMP in the cytosolic compartment sufficient to induce endothelial cell gaps. ExoY increased phosphorylation of tau at Ser 214.
Formal Description
Interaction-ID: 19692

gene/protein

exoY

increases_activity of

gene/protein

MAPT

Comment cAMP signals are strictly compartmentalized. cAMP emanating from soluble ACs (adenylyl cyclase) activates barrier-disrupting targets, such as tau. P. aeruginosa secretes the cytosolic exotoxin, ExoY, a adenylyl cyclase, into PMVECs (pulmonary microvascular endothelial cells). ExoY utilizes a eukaryotic factor to stimulate AC activity, generating cAMP in the cytosolic compartment sufficient to induce endothelial cell gaps. ExoY increased phosphorylation of tau at Ser 214.
Formal Description
Interaction-ID: 19713

gene/protein

exoY

increases_phosphorylation of

gene/protein

MAPT

at Ser 214
Comment cAMP signals are strictly compartmentalized. cAMP emanating from transmembrane ACs (adenylyl cyclase) activates barrier-enhancing targets. Isoproterenol stimulation of transmembrane AC (AC6) activity leads to an increase in filamin A phosphorylation at serine 2152 without changing total filamin A levels.
Formal Description
Interaction-ID: 19714

gene/protein

ADCY6

increases_phosphorylation of

gene/protein

FLNA

at Ser 2152