General Information:

Id: 2,285 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Heeb S et al.(2011) Quinolones: from antibiotics to autoinducers. FEMS Microbiol. Rev. 35: 247-274 [PMID: 20738404]

Interaction Information:

Comment Clinical isolates from sputum in CF (cystic fibrosis) patients showed that they all produced PQS and also HHQ, HQNO, NQNO and UQNO. In addition, there was a correlation between the levels of PQS and the bacterial sample load.
Formal Description
Interaction-ID: 19608

process

P. aeruginosa infection, chronic

increases_quantity of

drug/chemical compound

2-Heptyl-3-hydroxy-4-quinolone, PQS

in sputum of CF patients
Comment Clinical isolates from sputum in CF (cystic fibrosis) patients showed that they all produced PQS and also HHQ, HQNO, NQNO and UQNO. In addition, there was a correlation between the levels of PQS and the bacterial sample load.
Formal Description
Interaction-ID: 19609

process

P. aeruginosa infection, chronic

increases_quantity of

drug/chemical compound

2-Heptyl-4-quinolone, HHQ

in sputum of CF patients
Comment Clinical isolates from sputum in CF (cystic fibrosis) patients showed that they all produced PQS and also HHQ, HQNO, NQNO and UQNO. In addition, there was a correlation between the levels of PQS and the bacterial sample load.
Formal Description
Interaction-ID: 19610

process

P. aeruginosa infection, chronic

increases_quantity of

drug/chemical compound

2-Heptyl-4-hydroxyquinoline N-oxide, HQNO

in sputum of CF patients
Comment Clinical isolates from sputum in CF (cystic fibrosis) patients showed that they all produced PQS and also HHQ, HQNO, NQNO and UQNO. In addition, there was a correlation between the levels of PQS and the bacterial sample load.
Formal Description
Interaction-ID: 19611

process

P. aeruginosa infection, chronic

increases_quantity of

drug/chemical compound

2-Nonyl-4-hydroxyquinoline N-oxide, NQNO

in sputum of CF patients
Comment Clinical isolates from sputum in CF (cystic fibrosis) patients showed that they all produced PQS and also HHQ, HQNO, NQNO and UQNO. In addition, there was a correlation between the levels of PQS and the bacterial sample load.
Formal Description
Interaction-ID: 19612

process

P. aeruginosa infection, chronic

increases_quantity of

drug/chemical compound

2-Undecyl-4-hydroxyquinoline N-oxide, UQNO

in sputum of CF patients
Comment The expression of the phnAB genes is induced 14-22-fold, in line with the upregulation of the pqsABCDE operon (17-19-fold) in clinical isolates from sputum in CF (cystic fibrosis) patients compared with the expression of these genes in a morpholinepropanesulphonic acid-buffered glucose medium.
Formal Description
Interaction-ID: 19613

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

phnA

in sputum of CF patients
Drugbank entries Show/Hide entries for phnA
Comment The expression of the phnAB genes is induced 14-22-fold, in line with the upregulation of the pqsABCDE operon (17-19-fold) in clinical isolates from sputum in CF (cystic fibrosis) patients compared with the expression of these genes in a morpholinepropanesulphonic acid-buffered glucose medium.
Formal Description
Interaction-ID: 19614

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

phnB

in sputum of CF patients
Comment The expression of the phnAB genes is induced 14-22-fold, in line with the upregulation of the pqsABCDE operon (17-19-fold) in clinical isolates from sputum in CF (cystic fibrosis) patients compared with the expression of these genes in a morpholinepropanesulphonic acid-buffered glucose medium.
Formal Description
Interaction-ID: 19615

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

pqsA

in sputum of CF patients
Comment The expression of the phnAB genes is induced 14-22-fold, in line with the upregulation of the pqsABCDE operon (17-19-fold) in clinical isolates from sputum in CF (cystic fibrosis) patients compared with the expression of these genes in a morpholinepropanesulphonic acid-buffered glucose medium.
Formal Description
Interaction-ID: 19616

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

pqsB

in sputum of CF patients
Comment The expression of the phnAB genes is induced 14-22-fold, in line with the upregulation of the pqsABCDE operon (17-19-fold) in clinical isolates from sputum in CF (cystic fibrosis) patients compared with the expression of these genes in a morpholinepropanesulphonic acid-buffered glucose medium.
Formal Description
Interaction-ID: 19618

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

pqsC

in sputum of CF patients
Comment The expression of the phnAB genes is induced 14-22-fold, in line with the upregulation of the pqsABCDE operon (17-19-fold) in clinical isolates from sputum in CF (cystic fibrosis) patients compared with the expression of these genes in a morpholinepropanesulphonic acid-buffered glucose medium.
Formal Description
Interaction-ID: 19619

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

pqsD

in sputum of CF patients
Comment The expression of the phnAB genes is induced 14-22-fold, in line with the upregulation of the pqsABCDE operon (17-19-fold) in clinical isolates from sputum in CF (cystic fibrosis) patients compared with the expression of these genes in a morpholinepropanesulphonic acid-buffered glucose medium.
Formal Description
Interaction-ID: 19621

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

pqsE

in sputum of CF patients