General Information:

Id: 2,285 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Heeb S et al.(2011) Quinolones: from antibiotics to autoinducers. FEMS Microbiol. Rev. 35: 247-274 [PMID: 20738404]

Interaction Information:

Comment LasR will induce the production of virulence factors such as elastase and pyoverdin, while RhlR will increase the production of rhamnolipid biosurfactants, cytotoxic lectins, pyocyanin and elastase, among other virulence factors.
Formal Description
Interaction-ID: 19513

gene/protein

lasR

increases_quantity of

gene/protein

lasB

Drugbank entries Show/Hide entries for lasR or lasB
Comment LasR will induce the production of virulence factors such as elastase and pyoverdin, while RhlR will increase the production of rhamnolipid biosurfactants, cytotoxic lectins, pyocyanin and elastase, among other virulence factors.
Formal Description
Interaction-ID: 19517

gene/protein

rhlR

increases_quantity of

gene/protein

lasB

Drugbank entries Show/Hide entries for lasB
Comment PQS positively controlled the expression of the lasB (elastase) gene. It was later shown that this effect was considerably enhanced when PQS and C4-HSL acted synergistically to upregulate lasB expression.
Formal Description
Interaction-ID: 19572

drug/chemical compound

2-Heptyl-3-hydroxy-4-quinolone, PQS

increases_expression of

gene/protein

lasB

Drugbank entries Show/Hide entries for lasB
Comment PQS positively controlled the expression of the lasB (elastase) gene. It was later shown that this effect was considerably enhanced when PQS and C4-HSL acted synergistically to upregulate lasB expression.
Formal Description
Interaction-ID: 19573

drug/chemical compound

N-Butyryl-HSL

increases_expression of

gene/protein

lasB

Drugbank entries Show/Hide entries for lasB