General Information:

Id: 2,285 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Heeb S et al.(2011) Quinolones: from antibiotics to autoinducers. FEMS Microbiol. Rev. 35: 247-274 [PMID: 20738404]

Interaction Information:

Comment PqsH is regulated by LasR, but not by PqsR.
Formal Description
Interaction-ID: 19486

gene/protein

mvfR

NOT affects_expression of

gene/protein

pqsH

Comment HHQ (2-heptyl-4-quinolone) acts as an autoinducer independent of PQS (Pseudomonas quinolone signal) . Other AQs (2-alkyl-4(1H)-quinolones), such as NHQ (2-nonyl-4-hydroxyquinoline) can also activate PqsR and as such could potentially be considered as autoinducers, although not as potent as PQS.
Formal Description
Interaction-ID: 19520

drug/chemical compound

2-Heptyl-4-quinolone, HHQ

increases_activity of

gene/protein

mvfR

Comment HHQ (2-heptyl-4-quinolone) acts as an autoinducer independent of PQS (Pseudomonas quinolone signal) . Other AQs (2-alkyl-4(1H)-quinolones), such as NHQ (2-nonyl-4-hydroxyquinoline) can also activate PqsR and as such could potentially be considered as autoinducers, although not as potent as PQS.
Formal Description
Interaction-ID: 19521

drug/chemical compound

2-Nonyl-4-hydroxyquinoline, NHQ

increases_activity of

gene/protein

mvfR

Comment PmpR, a protein of the YebC-like superfamily, binds to the pqsR promoter and affects its transcription negatively.
Formal Description
Interaction-ID: 19590

gene/protein

pmpR

decreases_expression of

gene/protein

mvfR

Comment Farnesol, a sesquiterpene signal molecule produced by C. albicans, reduces the transcription of pqsA by interacting with PqsR, resulting in a decrease in both PQS and pyocyanin production.
Formal Description
Interaction-ID: 19634

drug/chemical compound

2-trans,6-trans-Farnesol

affects_activity of

gene/protein

mvfR