General Information:

Id: 2,214 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Dubern JF and Diggle SP(2008) Quorum sensing by 2-alkyl-4-quinolones in Pseudomonas aeruginosa and other bacterial species. Mol Biosyst 4: 882-888 [PMID: 18704225]

Interaction Information:

Comment In early immunological experiments, 3-oxo-C12-HSL was shown to suppress interleukin-12 (IL-12 ) and tumor necrosis factor alpha (TNF-alpha) secretion by LPS-stimulated macrophages and to eliminate T-cell proliferation.
Formal Description
Interaction-ID: 18809

drug/chemical compound

N-(3-Oxododecanoyl)-HSL

decreases_quantity of

gene/protein

TNF

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