General Information:

Id: 2,214 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Dubern JF and Diggle SP(2008) Quorum sensing by 2-alkyl-4-quinolones in Pseudomonas aeruginosa and other bacterial species. Mol Biosyst 4: 882-888 [PMID: 18704225]

Interaction Information:

Comment The regulation of the AQ (2-alkyl-4-quinolones) biosynthetic genes including the phnAB and pqsABCDE operons, occurs through a LysR family transcriptional regulator called PqsR (MvfR), which is positively controlled by LasR/3-oxo-C12-HSL.
Formal Description
Interaction-ID: 18672

gene/protein

mvfR

affects_expression of

gene/protein

phnA

Drugbank entries Show/Hide entries for phnA
Comment The regulation of the AQ (2-alkyl-4-quinolones) biosynthetic genes including the phnAB and pqsABCDE operons, occurs through a LysR family transcriptional regulator called PqsR (MvfR), which is positively controlled by LasR/3-oxo-C12-HSL.
Formal Description
Interaction-ID: 18673

gene/protein

mvfR

affects_expression of

gene/protein

phnB

Comment The regulation of the AQ (2-alkyl-4-quinolones) biosynthetic genes including the phnAB and pqsABCDE operons ,occurs through a LysR family transcriptional regulator called PqsR (MvfR), which is positively controlled by LasR/3-oxo-C12-HSL.
Formal Description
Interaction-ID: 18675

gene/protein

mvfR

affects_expression of

gene/protein

pqsA

Comment The regulation of the AQ (2-alkyl-4-quinolones) biosynthetic genes including the phnAB and pqsABCDE operons, occurs through a LysR family transcriptional regulator called PqsR (MvfR), which is positively controlled by LasR/3-oxo-C12-HSL.
Formal Description
Interaction-ID: 18676

gene/protein

mvfR

affects_expression of

gene/protein

pqsB

Comment The regulation of the AQ (2-alkyl-4-quinolones) biosynthetic genes including the phnAB and pqsABCDE operons, occurs through a LysR family transcriptional regulator called PqsR (MvfR), which is positively controlled by LasR/3-oxo-C12-HSL.
Formal Description
Interaction-ID: 18677

gene/protein

mvfR

affects_expression of

gene/protein

pqsC

Comment The regulation of the AQ (2-alkyl-4-quinolones) biosynthetic genes including the phnAB and pqsABCDE operons, occurs through a LysR family transcriptional regulator called PqsR (MvfR), which is positively controlled by LasR/3-oxo-C12-HSL.
Formal Description
Interaction-ID: 18678

gene/protein

mvfR

affects_expression of

gene/protein

pqsD

Comment PqsR binds the promoter of pqsABCDE but this binding increases dramatically in the presence of PQS, suggesting that PQS acts as a PqsR co-inducer.
Formal Description
Interaction-ID: 18679

drug/chemical compound

2-Heptyl-3-hydroxy-4-quinolone, PQS

increases_activity of

gene/protein

mvfR

Comment HHQ can also potentiate PqsR binding to the pqsABCDE promoter. Not only that, PQS is fully dispensable, as a pqsH mutant which produces HHQ but no PQS displayed normal PqsR-dependent gene expression and virulence.
Formal Description
Interaction-ID: 18680

drug/chemical compound

2-Heptyl-4-quinolone, HHQ

increases_activity of

gene/protein

mvfR

Comment pqsABCDE expression depends on the ratio between the two AHL molecules, 3-oxo-C12-HSL having a positive effect, and C4-HSL having a negative effect and that pqsR was a target for a negative regulation by rhl system. Las and rhl systems act antagonistically on pqsR regulation.
Formal Description
Interaction-ID: 18685

gene/protein

lasR

increases_activity of

gene/protein

mvfR

Drugbank entries Show/Hide entries for lasR
Comment pqsABCDE expression depends on the ratio between the two AHL molecules, 3-oxo-C12-HSL having a positive effect, and C4-HSL having a negative effect and that pqsR was a target for a negative regulation by rhl system. Las and rhl systems act antagonistically on pqsR regulation.
Formal Description
Interaction-ID: 18686

gene/protein

rhlR

decreases_activity of

gene/protein

mvfR

Comment The regulation of the AQ (2-alkyl-4-quinolones) biosynthetic genes including the phnAB and pqsABCDE operons ,occurs through a LysR family transcriptional regulator called PqsR (MvfR), which is positively controlled by LasR/3-oxo-C12-HSL.
Formal Description
Interaction-ID: 19225

gene/protein

mvfR

affects_expression of

gene/protein

pqsE