General Information:

Id: 2,210 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
Reference: Bjarnsholt T et al.(2010) Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control. Expert Rev Mol Med 12: E11 [PMID: 20370936]

Interaction Information:

Comment High intracellular levels of c-di-GMP (cyclic di-guanosine-5'-monophosphate) upregulate matrix production and biofilm formation. Low intracellular levels downregulate matrix production and induce planktonic life style.
Formal Description
Interaction-ID: 18873

drug/chemical compound


increases_activity of

Comment Pseudomonas aeruginosa produces a small organic compound cis-2-decenoic acid, which induces dispersion of established biofilms.
Formal Description
Interaction-ID: 18905

drug/chemical compound

cis-2-Decenoic acid

affects_activity of

biofilm dispersion
Comment An important link between biofilm stabilty and QS (quorum sensing) is the release of extracellular DNA (eDNA), which is regulated bei QS. eDNA has been shown to be a component of the matrix in P. aeruginosa biofilms.
Formal Description
Interaction-ID: 18935

cellular component

extracellular DNA, eDNA

increases_activity of

in the matrix of P. aeruginosa biofilms