General Information:

Id: 2,199 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Furlong CE et al.(2010) Human PON1, a biomarker of risk of disease and exposure. Chem. Biol. Interact. 187: 355-361 [PMID: 20338154]

Interaction Information:

Comment In addition to the role of PON1 in protecting against OP (organophosphorus pesticides) exposure and the importance of all three PONs in modulating oxidative stress, all three PONs appear to function in innate immunity via their abilities to inactivate bacterial quorum sensing factors. All three PONs hydrolyzed the quorum sensing factor of Pseudomonas aeruginosa N-3-oxododecanoyl homoserine lactone (3OC12-HSL).
Formal Description
Interaction-ID: 18378

gene/protein

PON2

decreases_quantity of

drug/chemical compound

N-(3-Oxododecanoyl)-HSL