General Information:

Id: 2,199
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Furlong CE et al.(2010) Human PON1, a biomarker of risk of disease and exposure. Chem. Biol. Interact. 187: 355-361 [PMID: 20338154]

Interaction Information:

Comment In addition to the role of PON1 in protecting against OP (organophosphorus pesticides) exposure and the importance of all three PONs in modulating oxidative stress, all three PONs appear to function in innate immunity via their abilities to inactivate bacterial quorum sensing factors. All three PONs hydrolyzed the quorum sensing factor of Pseudomonas aeruginosa N-3-oxododecanoyl homoserine lactone (3OC12-HSL).
Formal Description
Interaction-ID: 18364

gene/protein

PON1

decreases_activity of

process

Acyl-HSL quorum sensing

Drugbank entries Show/Hide entries for PON1
Comment In addition to the role of PON1 in protecting against OP (organophosphorus pesticides) exposure and the importance of all three PONs in modulating oxidative stress, all three PONs appear to function in innate immunity via their abilities to inactivate bacterial quorum sensing factors. All three PONs hydrolyzed the quorum sensing factor of Pseudomonas aeruginosa N-3-oxododecanoyl homoserine lactone (3OC12-HSL).
Formal Description
Interaction-ID: 18373

gene/protein

PON1

decreases_quantity of

drug/chemical compound

N-(3-Oxododecanoyl)-HSL

Drugbank entries Show/Hide entries for PON1
Comment In addition to the role of PON1 in protecting against OP (organophosphorus pesticides) exposure and the importance of all three PONs in modulating oxidative stress, all three PONs appear to function in innate immunity via their abilities to inactivate bacterial quorum sensing factors. All three PONs hydrolyzed the quorum sensing factor of Pseudomonas aeruginosa N-3-oxododecanoyl homoserine lactone (3OC12-HSL).
Formal Description
Interaction-ID: 18377

gene/protein

PON2

decreases_activity of

process

Acyl-HSL quorum sensing

Comment In addition to the role of PON1 in protecting against OP (organophosphorus pesticides) exposure and the importance of all three PONs in modulating oxidative stress, all three PONs appear to function in innate immunity via their abilities to inactivate bacterial quorum sensing factors. All three PONs hydrolyzed the quorum sensing factor of Pseudomonas aeruginosa N-3-oxododecanoyl homoserine lactone (3OC12-HSL).
Formal Description
Interaction-ID: 18378

gene/protein

PON2

decreases_quantity of

drug/chemical compound

N-(3-Oxododecanoyl)-HSL

Comment In addition to the role of PON1 in protecting against OP (organophosphorus pesticides) exposure and the importance of all three PONs in modulating oxidative stress, all three PONs appear to function in innate immunity via their abilities to inactivate bacterial quorum sensing factors. All three PONs hydrolyzed the quorum sensing factor of Pseudomonas aeruginosa N-3-oxododecanoyl homoserine lactone (3OC12-HSL).
Formal Description
Interaction-ID: 18379

gene/protein

PON3

decreases_activity of

process

Acyl-HSL quorum sensing

Comment In addition to the role of PON1 in protecting against OP (organophosphorus pesticides) exposure and the importance of all three PONs in modulating oxidative stress, all three PONs appear to function in innate immunity via their abilities to inactivate bacterial quorum sensing factors. All three PONs hydrolyzed the quorum sensing factor of Pseudomonas aeruginosa N-3-oxododecanoyl homoserine lactone (3OC12-HSL).
Formal Description
Interaction-ID: 18380

gene/protein

PON3

decreases_quantity of

drug/chemical compound

N-(3-Oxododecanoyl)-HSL