General Information:

Id: 2,144
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Williams BJ et al.(2010) Pseudomonas aeruginosa: host defence in lung diseases. Respirology 15: 1037-1056 [PMID: 20723140]

Interaction Information:

Comment The LasR quorum sensing pheromone, N-(3-oxododecanoyl)-L-homoserine lactone, can directly interact with host cells inducing apoptosis in neutrophils and stimulating IL-8 production in bronchial epithelial cells.
Formal Description
Interaction-ID: 17878

process

Acyl-HSL quorum sensing

increases_activity of

in neutrophils of bronchial epithelial cells
Comment The LasR quorum sensing pheromone, N-(3-oxododecanoyl)-L-homoserine lactone, can directly interact with host cells inducing apoptosis in neutrophils and stimulating IL-8 production in bronchial epithelial cells.
Formal Description
Interaction-ID: 17879

drug/chemical compound

N-(3-Oxododecanoyl)-HSL

increases_quantity of

gene/protein

CXCL8

in bronchial epithelial cells
Comment PLUNC, or palate lung nasal epithelium clone, is a protein secreted by human respiratory epithelial cells that is related to the bactericidal/permeability protein and works as both a surfactant and a bactericidal agent. PLUNC was recently shown to exhibit anti-biofilm activity in an in vitro model.
Formal Description
Interaction-ID: 17882

gene/protein

BPIFA1

decreases_activity of

in an in vitro model