General Information:

Id: 2,123 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
Reference: Sadikot RT et al.(2005) Pathogen-host interactions in Pseudomonas aeruginosa pneumonia Am. J. Respir. Crit. Care Med. 171: 1209-1223 [PMID: 15695491]

Interaction Information:

Comment Quorum-sensing molecules have the potential to directly modulate the host immune system. AHL (acyl homoserine lactones) induced cyclooxygenase-2 (COX-2) production in host cells through activation of NF-(kappa)B. COX-2 expression was linked to production of Prostaglandin E2 (PGE2), which has been shown to induce mucus secretion and promote vasodilation and edema.
Formal Description
Interaction-ID: 17566

drug/chemical compound

Prostaglandin E2

increases_activity of



in P. aeruginosa infected host