General Information:

Id: 2,123 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Sadikot RT et al.(2005) Pathogen-host interactions in Pseudomonas aeruginosa pneumonia Am. J. Respir. Crit. Care Med. 171: 1209-1223 [PMID: 15695491]

Interaction Information:

Comment The type III secretion system consists of three components: the secretion apparatus, the translocation or targeting apparatus, and the secreted toxins (effector proteins) and cognate chaperones. P. aeruginosa secretes four known effector proteins via type III secretion system: ExoS, ExoT, ExoU, and ExoY.
Formal Description
Interaction-ID: 17528

process

T3SS

increases_transport of

gene/protein

exoS

into the host cell
Comment ExoS was shown to induce TNF-alpha production via an MyD88-dependent pathway through activation of both TLR2 and TLR4.
Formal Description
Interaction-ID: 17537

gene/protein

exoS

increases_quantity of

gene/protein

TNF

Drugbank entries Show/Hide entries for TNF
Comment ExoS was shown to induce TNF-alpha production via an MyD88-dependent pathway through activation of both TLR2 and TLR4.
Formal Description
Interaction-ID: 17539

gene/protein

exoS

increases_activity of

gene/protein

TLR2

Drugbank entries Show/Hide entries for TLR2
Comment ExoS was shown to induce TNF-alpha production via an MyD88-dependent pathway through activation of both TLR2 and TLR4.
Formal Description
Interaction-ID: 17540

gene/protein

exoS

increases_activity of

gene/protein

TLR4

Drugbank entries Show/Hide entries for TLR4