General Information:

Id: 2,123 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
Reference: Sadikot RT et al.(2005) Pathogen-host interactions in Pseudomonas aeruginosa pneumonia Am. J. Respir. Crit. Care Med. 171: 1209-1223 [PMID: 15695491]

Interaction Information:

Comment P. aeruginosa expresses a limited number of polar pili, which are involved in attachment to eukaryotic cells. They bind to the GalNac-beta1-4 gal moiety exposed on asialylated glycolipids and then activate NF-(kappa)B and proinflammatory gene expression through a receptor complex that includes asialoGM1, Toll-like receptor 2 (TLR2), and associated kinases in a lipid raft.
Formal Description
Interaction-ID: 17519

cellular component

type IV pilus

increases_activity of