General Information:

Id: 2,123 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Sadikot RT et al.(2005) Pathogen-host interactions in Pseudomonas aeruginosa pneumonia Am. J. Respir. Crit. Care Med. 171: 1209-1223 [PMID: 15695491]

Interaction Information:

Comment Patients with CF (cystic fribrosis) have a high frequency of P. aeruginosa isolates with a phenotypic variant capable of forming biofilms related to a regulatory protein (PvrR).
Formal Description
Interaction-ID: 17446

gene/protein

pvrR

affects_activity of

in patients with CF
Comment The activation of the quorum-sensing cascade promotes the formation of biofilms, structured communities that coat mucosal surfaces and invasive devices. The formation of biofilms makes conditions more favorable for bacterial persistence in the lungs.
Formal Description
Interaction-ID: 17556

process

Acyl-HSL quorum sensing

increases_activity of

in P. aeruginosa infected host
Comment The activation of the quorum-sensing cascade promotes the formation of biofilms, structured communities that coat mucosal surfaces and invasive devices. The formation of biofilms makes conditions more favorable for bacterial persistence in the lungs.
Formal Description
Interaction-ID: 17557

process

P. aeruginosa infection

increases_activity of

Comment Alginate production or mucoidy is another prominent feature of P. aeruginosa encountered in patients with CF (cystic fribrosis). Conversion to a mucoid strain, which is dependent on biofilm formation, has been associated with establishment of chronic infection in CF.
Formal Description
Interaction-ID: 40196

cellular component

(alginate)n

increases_activity of

in patients with CF