General Information:

Id: 2,123 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Sadikot RT et al.(2005) Pathogen-host interactions in Pseudomonas aeruginosa pneumonia Am. J. Respir. Crit. Care Med. 171: 1209-1223 [PMID: 15695491]

Interaction Information:

Comment P. aeruginosa is the most prevalent chronic infection contributing to the pathogenesis of cystic fibrosis.
Formal Description
Interaction-ID: 17407

process

P. aeruginosa infection, chronic

increases_activity of

disease

Cystic fibrosis

Comment Alginate production or mucoidy is another prominent feature of P. aeruginosa encountered in patients with CF (cystic fribrosis). Conversion to a mucoid strain, which is dependent on biofilm formation, has been associated with establishment of chronic infection in CF.
Formal Description
Interaction-ID: 17448

process

P. aeruginosa infection, chronic

increases_quantity of

phenotype

mucoid strain

in patients with CF
Comment Other phenotypic changes in P. aeruginosa isolated from patients with CF (cystic fribrosis) include lack of flagellin or pilin expression.
Formal Description
Interaction-ID: 17449

process

P. aeruginosa infection, chronic

decreases_quantity of

cellular component

flagellum

in patients with CF
Comment Other phenotypic changes in P. aeruginosa isolated from patients with CF (cystic fribrosis) include lack of flagellin or pilin expression.
Formal Description
Interaction-ID: 17450

process

P. aeruginosa infection, chronic

decreases_quantity of

cellular component

type IV pilus

in patients with CF
Comment Levels of SP-A and SP-D have been shown to be decreased in the lungs of patients with CF (cystic fribrosis).
Formal Description
Interaction-ID: 17833

process

P. aeruginosa infection, chronic

decreases_quantity of

gene/protein

SFTPA1

in patients with CF
Drugbank entries Show/Hide entries for SFTPA1
Comment Levels of SP-A and SP-D have been shown to be decreased in the lungs of patients with CF (cystic fribrosis).
Formal Description
Interaction-ID: 17834

process

P. aeruginosa infection, chronic

decreases_quantity of

gene/protein

SFTPD

in patients with CF
Drugbank entries Show/Hide entries for SFTPD