General Information:

Id: 2,120
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Parsek MR and Greenberg EP(2000) Acyl-homoserine lactone quorum sensing in gram-negative bacteria: a signaling mechanism involved in associations with higher organisms. Proc. Natl. Acad. Sci. U.S.A. 97: 8789-8793 [PMID: 10922036]

Interaction Information:

Comment Acyl-homoserine lactone signaling in P. aeruginosa is a model for the relationships among quorum sensing, pathogenesis, and community behavior. In the P. aeruginosa model, quorum sensing is required for normal biofilm maturation and for virulence.
Formal Description
Interaction-ID: 17343

process

Acyl-HSL quorum sensing

increases_activity of

in P.aeruginosa
Comment Acyl-homoserine lactone signaling in P. aeruginosa is a model for the relationships among quorum sensing, pathogenesis, and community behavior. In the P. aeruginosa model, quorum sensing is required for normal biofilm maturation and for virulence.
Formal Description
Interaction-ID: 17344

process

P. aeruginosa infection

affects_activity of

process

Acyl-HSL quorum sensing

Comment Acyl-HSL (homoserine lactone) signaling represents a dedicated communication system that is used by bacteria to control specific genes in response to population density. P. aeruginosa RhlI primarily catalyzes the synthesis of N-butyryl-HSL (C4-HSL), and P. aeruginosa LasI directs the synthesis of N-(3-oxododecanoyl)-HSL (3OC12-HSL).
Formal Description
Interaction-ID: 17345

gene/protein

rhlI

increases_quantity of

drug/chemical compound

N-Butyryl-HSL

Comment Acyl-HSL (homoserine lactone) signaling represents a dedicated communication system that is used by bacteria to control specific genes in response to population density. P. aeruginosa RhlI primarily catalyzes the synthesis of N-butyryl-HSL (C4-HSL), and P. aeruginosa LasI directs the synthesis of N-(3-oxododecanoyl)-HSL (3OC12-HSL).
Formal Description
Interaction-ID: 17346

gene/protein

lasI

increases_quantity of

drug/chemical compound

N-(3-Oxododecanoyl)-HSL

Comment Acyl-HSL (homoserine lactone) signaling represents a dedicated communication system that is used by bacteria to control specific genes in response to population density. P. aeruginosa RhlI primarily catalyzes the synthesis of N-butyryl-HSL (C4-HSL), and P. aeruginosa LasI directs the synthesis of N-(3-oxododecanoyl)-HSL (3OC12-HSL).
Formal Description
Interaction-ID: 17347

drug/chemical compound

N-(3-Oxododecanoyl)-HSL

affects_activity of

process

Acyl-HSL quorum sensing

in P.aeruginosa
Comment LasR is a transcriptional regulator that responds primarily to the LasI-generated signal, 3OC12-HSL, and RhlR is a transcriptional regulator that responds best to the RhlI-generated signal, C4-HSL.
Formal Description
Interaction-ID: 17348

drug/chemical compound

N-(3-Oxododecanoyl)-HSL

increases_activity of

gene/protein

lasR

in P.aeruginosa
Drugbank entries Show/Hide entries for lasR
Comment LasR is a transcriptional regulator that responds primarily to the LasI-generated signal, 3OC12-HSL, and RhlR is a transcriptional regulator that responds best to the RhlI-generated signal, C4-HSL.
Formal Description
Interaction-ID: 17349

drug/chemical compound

N-Butyryl-HSL

increases_activity of

gene/protein

rhlR

in P.aeruginosa
Comment LasR-3OC12-HSL complex activates transcription of a number of genes. The list of target genes includes lasB, toxA, rhlR, and lasI.
Formal Description
Interaction-ID: 17352

process

LasR/I-3OC12-(HSL)-system

increases_expression of

gene/protein

lasB

in P.aeruginosa
Drugbank entries Show/Hide entries for lasB
Comment LasR-3OC12-HSL complex activates transcription of a number of genes. The list of target genes includes lasB, toxA, rhlR, and lasI.
Formal Description
Interaction-ID: 17353

process

LasR/I-3OC12-(HSL)-system

increases_expression of

gene/protein

toxA

in P.aeruginosa
Drugbank entries Show/Hide entries for toxA
Comment LasR-3OC12-HSL complex activates transcription of a number of genes. The list of target genes includes lasB, toxA, rhlR, and lasI.
Formal Description
Interaction-ID: 17354

process

LasR/I-3OC12-(HSL)-system

increases_expression of

gene/protein

rhlR

in P.aeruginosa
Comment LasR-3OC12-HSL complex activates transcription of a number of genes. The list of target genes includes lasB, toxA, rhlR, and lasI.
Formal Description
Interaction-ID: 17355

gene/protein

lasR

increases_expression of

gene/protein

lasI

in P.aeruginosa
Drugbank entries Show/Hide entries for lasR
Comment Bacteria in these mature biofilms are phenotypically resistant to microbicidal agents, including antibiotics. Thus biofilms cause many different types of chronic or persistent bacterial infections.
Formal Description
Interaction-ID: 17378

increases_activity of

process

antibiotic resistance

in P.aeruginosa
Comment Acyl-HSL (homoserine lactone) signaling represents a dedicated communication system that is used by bacteria to control specific genes in response to population density. P. aeruginosa RhlI primarily catalyzes the synthesis of N-butyryl-HSL (C4-HSL), and P. aeruginosa LasI directs the synthesis of N-(3-oxododecanoyl)-HSL (3OC12-HSL).
Formal Description
Interaction-ID: 17561

drug/chemical compound

N-Butyryl-HSL

affects_activity of

process

Acyl-HSL quorum sensing

in P.aeruginosa
Comment Acyl-HSL (homoserine lactone) signaling represents a dedicated communication system that is used by bacteria to control specific genes in response to population density. P. aeruginosa RhlI primarily catalyzes the synthesis of N-butyryl-HSL (C4-HSL), and P. aeruginosa LasI directs the synthesis of N-(3-oxododecanoyl)-HSL (3OC12-HSL).
Formal Description
Interaction-ID: 29491

process

LasR/I-3OC12-(HSL)-system

affects_activity of

process

Acyl-HSL quorum sensing

Comment Acyl-HSL (homoserine lactone) signaling represents a dedicated communication system that is used by bacteria to control specific genes in response to population density. P. aeruginosa RhlI primarily catalyzes the synthesis of N-butyryl-HSL (C4-HSL), and P. aeruginosa LasI directs the synthesis of N-(3-oxododecanoyl)-HSL (3OC12-HSL).
Formal Description
Interaction-ID: 29492

process

RhlR/I-C4-(HSL)-system

affects_activity of

process

Acyl-HSL quorum sensing