General Information:

Id: 2,103 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: Ghigo E et al.(2009) Intracellular life of Coxiella burnetii in macrophages Ann. N. Y. Acad. Sci. 1166: 55-66 [PMID: 19538264]

Interaction Information:

Comment During the course of C. burnetii infection, TLR4 controls the bacterial uptake by macrophages.
Formal Description
Interaction-ID: 17157

process

Coxiella burnetii infection

increases_activity of

gene/protein

TLR4

in human macrophages
Drugbank entries Show/Hide entries for TLR4
Comment Besides its role in the uptake of phase I C. burnetii, TLR4 is also involved in C. burnetii-induced F-actin remodeling, highlighting again the close relationship between C. burnetii uptake and cytoskeletal organization.
Formal Description
Interaction-ID: 17160

process

Coxiella burnetii infection

affects_activity of

in human macrophages
Comment Similarly to TLR4, TLR2 is involved in the inflammatory and immune responses to C. burnetii, but is not necessary for bacterial clearance.
Formal Description
Interaction-ID: 36042

process

Coxiella burnetii infection

affects_activity of

gene/protein

TLR2

in human macrophages
Drugbank entries Show/Hide entries for TLR2