General Information:

Id: 2,103 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: Ghigo E et al.(2009) Intracellular life of Coxiella burnetii in macrophages Ann. N. Y. Acad. Sci. 1166: 55-66 [PMID: 19538264]

Interaction Information:

Comment C. burnetii bacteria are localized within a compartment (phagosome) that undergoes a series of fusion/fission events with different populations of endocytic organelles such as endosomes. The pH of early phagosomes is around 6.0, the acquisition of vacuolar proton pump ATPase (V-H+-ATPase) allows the intraphagosomal pH to reach an acidic pH around 4.0.
Formal Description
Interaction-ID: 17287

complex/PPI

Vacuolar proton-transporting V-type ATPase complex

increases_activity of

Comment Adding IFN-gamma to C. burnetii-infected monocytes stimulates phagosome-lysosome fusion, but does not affect vacuolar pH.
Formal Description
Interaction-ID: 32300

gene/protein

IFNG

NOT affects_activity of

in C. burnetii-infected monocytes
Drugbank entries Show/Hide entries for IFNG
Comment C. burnetii bacteria are localized within a compartment (phagosome) that undergoes a series of fusion/fission events with different populations of endocytic organelles such as endosomes. The pH of early phagosomes is around 6.0, the acquisition of vacuolar proton pump ATPase (V-H+-ATPase) allows the intraphagosomal pH to reach an acidic pH around 4.0.
Formal Description
Interaction-ID: 32935

increases_activity of

Comment Adding IFN-gamma to C. burnetii-infected monocytes stimulates phagosome-lysosome fusion, but does not affect vacuolar pH. The treatment of monocytes by IFN-gamma prior C. burnetii infection induces the alkalinization of C. burnetii vacuoles independently of the V-H+-ATPase exclusion.
Formal Description
Interaction-ID: 37802

gene/protein

IFNG

affects_activity of

in C. burnetii-infected monocytes; treated with IFN-gamma prior to infection
Drugbank entries Show/Hide entries for IFNG