General Information:

Id: 2,062 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: Voth DE and Heinzen RA(2007) Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii Cell. Microbiol. 9: 829-840 [PMID: 17381428]

Interaction Information:

Comment The PV membrane has approximately the same cholesterol content as the cholesterol-rich plasma membrane. To compensate for biogenesis of the novel Coxiella compartment, infected cells produce 73% more cholesterol late in the pathogen's infectious cycle (6 days post infection) than uninfected cells, indicating a dramatic increase in cholesterol metabolism as opposed to simple redistribution of normal cholesterol stores. Accordingly, transcription of host genes involved in both cholesterol uptake (e.g. LDL receptor) and biosynthesis (e.g. lanosterol synthase) increases in response to the growth cycle of Coxiella, with upregulation of these genes observed only during log phase (about 4 days post infection), a time when the PV is dramatically expanding.
Formal Description
Interaction-ID: 17072

process

Coxiella burnetii infection

increases_quantity of

drug/chemical compound

host cell cholesterol

6 days post infection