General Information:

Id: 2,062 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: Voth DE and Heinzen RA(2007) Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii Cell. Microbiol. 9: 829-840 [PMID: 17381428]

Interaction Information:

Comment Pathogen interactions with autophagosomes can have either beneficial or detrimental effects. Coxiella clearly benefits from autophagy as induction of this pathway increases the number of infected cells, the size of the PV, and the extent of Coxiella replication. These effects are abolished when infected cells are treated with the autophagy inhibitors wortmannin and 3-methyladenine.
Formal Description
Interaction-ID: 17043

process

Coxiella burnetii infection

increases_activity of

process

autophagy

Comment Coxiella protein synthesis is required for early autophagosome interactions that promote stalling of PV maturation. Protein effectors of this process presumably target host factors that regulate vesicular trafficking and are likely delivered to the cytosol via the activity of a type IV secretion system (T4SS) that has homology to the Dot/Icm T4SS of Legionella.
Formal Description
Interaction-ID: 17050

process

Coxiella burnetii infection

increases_activity of

process

T4BSS

Comment The PV membrane has approximately the same cholesterol content as the cholesterol-rich plasma membrane. To compensate for biogenesis of the novel Coxiella compartment, infected cells produce 73% more cholesterol late in the pathogen's infectious cycle (6 days post infection) than uninfected cells, indicating a dramatic increase in cholesterol metabolism as opposed to simple redistribution of normal cholesterol stores. Accordingly, transcription of host genes involved in both cholesterol uptake (e.g. LDL receptor) and biosynthesis (e.g. lanosterol synthase) increases in response to the growth cycle of Coxiella, with upregulation of these genes observed only during log phase (about 4 days post infection), a time when the PV is dramatically expanding.
Formal Description
Interaction-ID: 17072

process

Coxiella burnetii infection

increases_quantity of

drug/chemical compound

host cell cholesterol

6 days post infection
Comment The PV membrane has approximately the same cholesterol content as the cholesterol-rich plasma membrane. To compensate for biogenesis of the novel Coxiella compartment, infected cells produce 73% more cholesterol late in the pathogen's infectious cycle (6 days post infection) than uninfected cells, indicating a dramatic increase in cholesterol metabolism as opposed to simple redistribution of normal cholesterol stores. Accordingly, transcription of host genes involved in both cholesterol uptake (e.g. LDL receptor) and biosynthesis (e.g. lanosterol synthase) increases in response to the growth cycle of Coxiella, with upregulation of these genes observed only during log phase (about 4 days post infection), a time when the PV is dramatically expanding.
Formal Description
Interaction-ID: 17074

process

Coxiella burnetii infection

increases_expression of

gene/protein

LDLR

observed only during log phase (about 4 days post infection)
Drugbank entries Show/Hide entries for LDLR
Comment The PV membrane has approximately the same cholesterol content as the cholesterol-rich plasma membrane. To compensate for biogenesis of the novel Coxiella compartment, infected cells produce 73% more cholesterol late in the pathogen's infectious cycle (6 days post infection) than uninfected cells, indicating a dramatic increase in cholesterol metabolism as opposed to simple redistribution of normal cholesterol stores. Accordingly, transcription of host genes involved in both cholesterol uptake (e.g. LDL receptor) and biosynthesis (e.g. lanosterol synthase) increases in response to the growth cycle of Coxiella, with upregulation of these genes observed only during log phase (about 4 days post infection), a time when the PV is dramatically expanding.
Formal Description
Interaction-ID: 17075

process

Coxiella burnetii infection

increases_expression of

gene/protein

LSS

observed only during log phase (about 4 days post infection)
Drugbank entries Show/Hide entries for LSS