General Information:

Id: 2,061 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: Shannon JG and Heinzen RA(2009) Adaptive immunity to the obligate intracellular pathogen Coxiella burnetii Immunol. Res. 43: 138-148 [PMID: 18813881]

Interaction Information:

Comment C. burnetii typically infects humans via the aerosol route and alveolar macrophages and other mononuclear phagocytes are believed to be the primary target cells of the pathogen.
Formal Description
Interaction-ID: 16517

process

Coxiella burnetii infection

is localized in

tissue/cell line

alveolar macrophage

Comment Virulent C. burnetii phase I strains are always isolated from an infected animal or patient and produce a full-length lipopolysaccharide (LPS).
Formal Description
Interaction-ID: 16523

organism

Coxiella burnetii, phase I

increases_activity of

process

Coxiella burnetii infection

Comment Repeated passage of C. burnetii phase I organisms in vitro results in conversion to a phase II phenotype where bacteria produce a truncated LPS molecule lacking the terminal O-antigen sugars. Phase II C. burnetii are severely attenuated and cannot establish an infection in an immunocompetent host.
Formal Description
Interaction-ID: 16524

organism

Coxiella burnetii, phase II

NOT increases_activity of

process

Coxiella burnetii infection

in an immunocompetent host
Comment Lymphocytes from vaccinated and convalescent humans proliferate and produce IFN-gamma in response to C. burnetii Ag.
Formal Description
Interaction-ID: 35043

process

Coxiella burnetii infection

increases_quantity of

gene/protein

IFNG

in lymphocytes from vaccinated and convalescent humans
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