General Information:

Id: 2,047 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: Vazquez CL and Colombo MI(2010) Beclin 1 modulates the anti-apoptotic activity of Bcl-2: insights from a pathogen infection system Autophagy 6: 177-178 [PMID: 20023428]

Interaction Information:

Comment C. burnetii presents a type IV secretion system (T4SS) that injects bacterial effectors into host cells.
Formal Description
Interaction-ID: 16356

process

Coxiella burnetii infection

increases_activity of

process

T4BSS

Comment C. burnetii infection promotes an increase in LC3 processing to the LC3-II form, and autophagosome formation, indicating that the infection with this bacterium induces autophagy.
Formal Description
Interaction-ID: 16414

process

Coxiella burnetii infection

increases_activity of

process

autophagy

Comment The anti-apoptotic activity of C. burnetii requires an appropriate interplay between Beclin 1 and Bcl-2, since the anti-apoptotic effect of C. burnetii was hampered when the expression of Beclin 1 was suppressed or when a Beclin 1 mutant unable to interact with Bcl-2 was overexpressed.
Formal Description
Interaction-ID: 16460

process

Coxiella burnetii infection

decreases_activity of

process

host cell apoptosis