General Information:

Id: 2,024 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
review
Reference: Oyston PC and Davies C(2011) Q fever: the neglected biothreat agent J. Med. Microbiol. 60: 9-21 [PMID: 21030501]

Interaction Information:

Comment Although IFN-gamma is key to controlling Q fever, apoptosis is closely controlled by the invading Coxiella to maintain viability of the host cell during the lengthy inhabitation. Infected host cells show decreased caspase activity, induction of a pro-survival transcriptional response, including Akt and Erk 1/2 activation, and decreased release of cytochrome c.
Formal Description
Interaction-ID: 16242

process

Coxiella burnetii infection

increases_activity of

in infected host cells