General Information:

Id: 2,017 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
BTO:0000798 BeWo cell, infected with Coxiella burnetii
article
Reference: Ben Amara A et al.(2010) Coxiella burnetii, the agent of Q fever, replicates within trophoblasts and induces a unique transcriptional response PLoS ONE 5 [PMID: 21179488]

Interaction Information:

Comment Coxiella burnetii stimulated gene networks organized around the IL-6 and IL-13 pathways, which both modulate STAT3.
Formal Description
Interaction-ID: 15981

process

Coxiella burnetii infection

increases_activity of

gene/protein

IL6

in BeWo trophoblasts
Drugbank entries Show/Hide entries for IL6
Comment Coxiella burnetii stimulated gene networks organized around the IL-6 and IL-13 pathways, which both modulate STAT3.
Formal Description
Interaction-ID: 15982

process

Coxiella burnetii infection

increases_activity of

gene/protein

IL13

in BeWo trophoblasts
Comment C.oxiella burnetii stimulated the transcriptional expression of EGR-1, whereas TNF had no effect on the transcription and protein expression levels of EGR-1.
Formal Description
Interaction-ID: 15984

process

Coxiella burnetii infection

increases_expression of

gene/protein

EGR1

in BeWo trophoblasts
Comment IL4R, MMP9, NDRG1 and TGF-beta 1 were up-regulated due to Coxiella burnetii infection, as shown in an microarray approach and RT-PCR.
Formal Description
Interaction-ID: 15985

process

Coxiella burnetii infection

increases_expression of

gene/protein

IL4R

in BeWo trophoblasts
Comment IL4R, MMP9, NDRG1 and TGF-beta 1 were up-regulated due to Coxiella burnetii infection, as shown in an microarray approach and RT-PCR.
Formal Description
Interaction-ID: 15986

process

Coxiella burnetii infection

increases_expression of

gene/protein

NDRG1

in BeWo trophoblasts
Comment IL4R, MMP9, NDRG1 and TGF-beta 1 were up-regulated due to Coxiella burnetii infection, as shown in an microarray approach and RT-PCR.
Formal Description
Interaction-ID: 15987

process

Coxiella burnetii infection

increases_expression of

gene/protein

TGFB1

in BeWo trophoblasts
Drugbank entries Show/Hide entries for TGFB1
Comment CXCR6, IFNGR2, MMP12, TNFAIP3, TNFSF10, CD83, FOS and S100A9 were up-regulated due to Coxiella burnetii infection,as shown in an microarray approach and RT-PCR.
Formal Description
Interaction-ID: 16038

process

Coxiella burnetii infection

increases_expression of

gene/protein

CXCR6

in BeWo trophoblasts
Comment CXCR6, IFNGR2, MMP12, TNFAIP3, TNFSF10, CD83, FOS and S100A9 were up-regulated due to Coxiella burnetii infection,as shown in an microarray approach and RT-PCR.
Formal Description
Interaction-ID: 16044

process

Coxiella burnetii infection

increases_expression of

gene/protein

IFNGR2

in BeWo trophoblasts
Drugbank entries Show/Hide entries for IFNGR2
Comment CXCR6, IFNGR2, MMP12, TNFAIP3, TNFSF10, CD83, FOS and S100A9 were up-regulated due to Coxiella burnetii infection,as shown in an microarray approach and RT-PCR.
Formal Description
Interaction-ID: 16051

process

Coxiella burnetii infection

increases_expression of

gene/protein

MMP12

in BeWo trophoblasts
Drugbank entries Show/Hide entries for MMP12
Comment CXCR6, IFNGR2, MMP12, TNFAIP3, TNFSF10, CD83, FOS and S100A9 were up-regulated due to Coxiella burnetii infection,as shown in an microarray approach and RT-PCR.
Formal Description
Interaction-ID: 16053

process

Coxiella burnetii infection

increases_expression of

gene/protein

TNFAIP3

in BeWo trophoblasts
Comment CXCR6, IFNGR2, MMP12, TNFAIP3, TNFSF10, CD83, FOS and S100A9 were up-regulated due to Coxiella burnetii infection,as shown in an microarray approach and RT-PCR.
Formal Description
Interaction-ID: 16054

process

Coxiella burnetii infection

increases_expression of

gene/protein

TNFSF10

in BeWo trophoblasts
Comment CXCR6, IFNGR2, MMP12, TNFAIP3, TNFSF10, CD83, FOS and S100A9 were up-regulated due to Coxiella burnetii infection,as shown in an microarray approach and RT-PCR.
Formal Description
Interaction-ID: 16055

process

Coxiella burnetii infection

increases_expression of

gene/protein

CD83

in BeWo trophoblasts
Comment CXCR6, IFNGR2, MMP12, TNFAIP3, TNFSF10, CD83, FOS and S100A9 were up-regulated due to Coxiella burnetii infection,as shown in an microarray approach and RT-PCR.
Formal Description
Interaction-ID: 16056

process

Coxiella burnetii infection

increases_expression of

gene/protein

FOS

in BeWo trophoblasts
Drugbank entries Show/Hide entries for FOS
Comment CXCR6, IFNGR2, MMP12, TNFAIP3, TNFSF10, CD83, FOS and S100A9 were up-regulated due to Coxiella burnetii infection,as shown in an microarray approach and RT-PCR.
Formal Description
Interaction-ID: 16057

process

Coxiella burnetii infection

increases_expression of

gene/protein

S100A9

in BeWo trophoblasts
Comment Coxiella burnetii infection depressed the expression of the INDO gene and increased expression of CASP5 as shown in an microarray approach and RT-PCR.
Formal Description
Interaction-ID: 16058

process

Coxiella burnetii infection

increases_expression of

gene/protein

CASP5

in BeWo trophoblasts
Comment Coxiella burnetii infection depressed the expression of the INDO gene and increased expression of CASP5 as shown in an microarray approach and RT-PCR.
Formal Description
Interaction-ID: 16060

process

Coxiella burnetii infection

decreases_expression of

gene/protein

IDO1

in BeWo trophoblasts
Comment In the network organized around IL6ST (IL6 signal transducer), 23 genes were up-regulated in response to Coxiella burnetii infection, including IL6ST, STAT3, JUN, IL27RA, CCND1 and RHO, as shown in an microarray approach.
Formal Description
Interaction-ID: 16067

process

Coxiella burnetii infection

increases_expression of

gene/protein

IL6ST

in BeWo trophoblasts
Comment In the network organized around IL6ST (IL6 signal transducer), 23 genes were up-regulated in response to Coxiella burnetii infection, including IL6ST, STAT3, JUN, IL27RA, CCND1 and RHO, as shown in an microarray approach.
Formal Description
Interaction-ID: 16075

process

Coxiella burnetii infection

increases_expression of

gene/protein

STAT3

in BeWo trophoblasts
Comment In the network organized around IL6ST (IL6 signal transducer), 23 genes were up-regulated in response to Coxiella burnetii infection, including IL6ST, STAT3, JUN, IL27RA, CCND1 and RHO, as shown in an microarray approach.
Formal Description
Interaction-ID: 16076

process

Coxiella burnetii infection

increases_expression of

gene/protein

JUN

in BeWo trophoblasts
Drugbank entries Show/Hide entries for JUN
Comment In the network organized around IL6ST (IL6 signal transducer), 23 genes were up-regulated in response to Coxiella burnetii infection, including IL6ST, STAT3, JUN, IL27RA, CCND1 and RHO, as shown in an microarray approach.
Formal Description
Interaction-ID: 16077

process

Coxiella burnetii infection

increases_expression of

gene/protein

IL27RA

in BeWo trophoblasts
Comment In the network organized around IL6ST (IL6 signal transducer), 23 genes were up-regulated in response to Coxiella burnetii infection, including IL6ST, STAT3, JUN, IL27RA, CCND1 and RHO, as shown in an microarray approach.
Formal Description
Interaction-ID: 16078

process

Coxiella burnetii infection

increases_expression of

gene/protein

CCND1

in BeWo trophoblasts
Drugbank entries Show/Hide entries for CCND1
Comment In the network organized around IL6ST (IL6 signal transducer), 23 genes were up-regulated in response to Coxiella burnetii infection, including IL6ST, STAT3, JUN, IL27RA, CCND1 and RHO, as shown in an microarray approach.
Formal Description
Interaction-ID: 16079

process

Coxiella burnetii infection

increases_expression of

gene/protein

RHO

in BeWo trophoblasts
Drugbank entries Show/Hide entries for RHO
Comment In the network organized around IL6ST (IL6 signal transducer), 25 genes were down-regulated in response to Coxiella burnetii infection, some were specific for C. burnetii, including IGF2, GFAP and PCSK1, as shown in an microarray approach.
Formal Description
Interaction-ID: 16080

process

Coxiella burnetii infection

decreases_expression of

gene/protein

IGF2

in BeWo trophoblasts
Comment In the network organized around IL6ST (IL6 signal transducer), 25 genes were down-regulated in response to Coxiella burnetii infection, some were specific for C. burnetii, including IGF2, GFAP and PCSK1, as shown in an microarray approach.
Formal Description
Interaction-ID: 16081

process

Coxiella burnetii infection

decreases_expression of

gene/protein

GFAP

in BeWo trophoblasts
Comment In the network organized around IL6ST (IL6 signal transducer), 25 genes were down-regulated in response to Coxiella burnetii infection, some were specific for C. burnetii, including IGF2, GFAP and PCSK1, as shown in an microarray approach.
Formal Description
Interaction-ID: 16082

process

Coxiella burnetii infection

decreases_expression of

gene/protein

PCSK1

in BeWo trophoblasts
Drugbank entries Show/Hide entries for PCSK1
Comment The network organized around IL13RA2 consisted of 7 seven genes, of which five were up-regulated (TGF beta 1, IL4R, ADM, STAT3, IL13RA1 and 2 were down-regulated, including IFN-gamma, as shown in an microarray approach.
Formal Description
Interaction-ID: 16083

process

Coxiella burnetii infection

increases_expression of

gene/protein

ADM

in BeWo trophoblasts
Comment The network organized around IL13RA2 consisted of 7 seven genes, of which five were up-regulated (TGF beta 1, IL4R, ADM, STAT3, IL13RA1 and 2 were down-regulated, including IFN-gamma, as shown in an microarray approach.
Formal Description
Interaction-ID: 16084

process

Coxiella burnetii infection

increases_expression of

gene/protein

IL13RA1

in BeWo trophoblasts
Comment The network organized around IL13RA2 consisted of 7 seven genes, of which five were up-regulated (TGF beta 1, IL4R, ADM, STAT3, IL13RA1 and 2 were down-regulated, including IFN-gamma, as shown in an microarray approach.
Formal Description
Interaction-ID: 16085

process

Coxiella burnetii infection

decreases_expression of

gene/protein

IFNG

in BeWo trophoblasts
Drugbank entries Show/Hide entries for IFNG