General Information:

Id: 3,893
Mus musculus
OP9 stromal cell line
Reference: Ichii M et al.(2012) The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells Blood 119: 1683-1692 [PMID: 22117039]

Interaction Information:

Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39381

gene/protein

Wnt3a

decreases_expression of

gene/protein

Kitl

in OP9 stromal cell line
Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39385

gene/protein

Wnt3a

decreases_expression of

gene/protein

Angpt1

in OP9 stromal cell line
Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39386

gene/protein

Wnt3a

decreases_expression of

gene/protein

Vcam1

in OP9 stromal cell line
Drugbank entries Show/Hide entries for Vcam1
Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39387

gene/protein

Wnt3a

increases_expression of

gene/protein

Wnt1

in OP9 stromal cell line
Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39390

gene/protein

Wnt3a

increases_expression of

gene/protein

Wnt5a

in OP9 stromal cell line
Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39391

gene/protein

Wnt3a

increases_expression of

gene/protein

Wnt7b

in OP9 stromal cell line
Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39392

gene/protein

Wnt3a

increases_expression of

gene/protein

Wnt9a

in OP9 stromal cell line
Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39393

gene/protein

Wnt3a

increases_expression of

gene/protein

Sfrp2

in OP9 stromal cell line
Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39394

gene/protein

Wnt3a

increases_expression of

gene/protein

Wif1

in OP9 stromal cell line
Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39395

tissue/cell line

OP9 stromal cell line

increases_expression of

gene/protein

Kitl

Expression is decreased if OP9 cells were transduced with Wnt3a
Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39400

tissue/cell line

OP9 stromal cell line

increases_expression of

gene/protein

Angpt1

Expression is decreased if OP9 cells were transduced with Wnt3a
Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39401

tissue/cell line

OP9 stromal cell line

increases_expression of

gene/protein

Vcam1

Expression is decreased if OP9 cells were transduced with Wnt3a
Drugbank entries Show/Hide entries for Vcam1
Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39402

tissue/cell line

OP9 stromal cell line

increases_expression of

gene/protein

Wnt1

Expression is increased if OP9 cells were transduced with Wnt3a
Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39403

tissue/cell line

OP9 stromal cell line

increases_expression of

gene/protein

Wnt5a

Expression is increased if OP9 cells were transduced with Wnt3a
Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39404

tissue/cell line

OP9 stromal cell line

increases_expression of

gene/protein

Wnt7b

Expression is increased if OP9 cells were transduced with Wnt3a
Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39405

tissue/cell line

OP9 stromal cell line

increases_expression of

gene/protein

Sfrp2

Expression is increased if OP9 cells were transduced with Wnt3a
Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39406

tissue/cell line

OP9 stromal cell line

increases_expression of

gene/protein

Wif1

Expression is increased if OP9 cells were transduced with Wnt3a
Comment OP9 cells transduced with Wnt3a down-regulate the expression of Ang1, KitL and VCAM-1. The expression of Wnt signaling ligands and modulators of Wnt signaling is increased. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39407

tissue/cell line

OP9 stromal cell line

increases_expression of

gene/protein

Wnt9a

Expression is increased if OP9 cells were transduced with Wnt3a
Comment The extracellular matrix protein decorin is increased more than 3000-fold after Wnt3a induction in OP9 stromal cells. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39409

tissue/cell line

OP9 stromal cell line

increases_expression of

gene/protein

Dcn

Expression is increased if OP9 cells were transduced with Wnt3a
Drugbank entries Show/Hide entries for Dcn
Comment The extracellular matrix protein decorin is increased more than 3000-fold after Wnt3a induction in OP9 stromal cells. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39410

gene/protein

Wnt3a

increases_expression of

gene/protein

Dcn

in OP9 stromal cell line about 3000-fold
Drugbank entries Show/Hide entries for Dcn
Comment Wnt3a induces the expression of matrix molecules, such as fibromodulin or tenascins in OP9 stromal cells. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39423

tissue/cell line

OP9 stromal cell line

increases_expression of

gene/protein

Fmod

Expression is increased if OP9 cells were transduced with Wnt3a
Comment Wnt3a induces the expression of matrix molecules, such as fibromodulin or tenascins in OP9 stromal cells. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39425

gene/protein

Wnt3a

increases_expression of

gene/protein

Fmod

in OP9 stromal cell line
Comment Wnt3a induces the expression of matrix molecules, such as fibromodulin or tenascins in OP9 stromal cells. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39429

tissue/cell line

OP9 stromal cell line

increases_expression of

gene/protein

Tnc

Expression is increased if OP9 cells were transduced with Wnt3a
Comment Wnt3a induces the expression of matrix molecules, such as fibromodulin or tenascins in OP9 stromal cells. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39430

gene/protein

Wnt3a

increases_expression of

gene/protein

Tnc

in OP9 stromal cell line
Comment Wnt3a induces the expression of matrix molecules, such as fibromodulin or tenascins in OP9 stromal cells. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39431

tissue/cell line

OP9 stromal cell line

increases_expression of

gene/protein

Tnn

Expression is increased if OP9 cells were transduced with Wnt3a
Comment Wnt3a induces the expression of matrix molecules, such as fibromodulin or tenascins in OP9 stromal cells. [Method: OP9 stromal cell line transduced with Wnt3a, qRT-PCR]
Formal Description
Interaction-ID: 39432

gene/protein

Wnt3a

increases_expression of

gene/protein

Tnn

in OP9 stromal cell line