General Information:

Id: 3,873 (click here to show other Interactions for entry)
Mus musculus
B6.SJL-Ptprc a/BoAiTac
Reference: Nemeth MJ et al.(2007) Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation Proc. Natl. Acad. Sci. U.S.A. 104 [PMID: 17881570]

Interaction Information:

Comment Under serum-free conditions, the presence of Wnt3a significantly reduced total cell expansion 3-fold after 4 days in culture compared with control conditions (SCF and Flt3L alone). However, Wnt5a either alone (12-fold) or in combination with Wnt3a (16-fold) also significantly reduced cell expansion compared with control conditions. [Method: Il-7Ralpha- KSL cells (isolated from TOPGAL mice) cultured with recombinant Wnt3a or Wnt5a]
Formal Description
Interaction-ID: 39028

gene/protein

Wnt3a

decreases_quantity of

Immunophenotype

HSC (CD127-KSL)

in vitro