General Information:

Id: 3,873 (click here to show other Interactions for entry)
Mus musculus
B6.SJL-Ptprc a/BoAiTac
Reference: Nemeth MJ et al.(2007) Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation Proc. Natl. Acad. Sci. U.S.A. 104 [PMID: 17881570]

Interaction Information:

Comment Wnt5a inhibits canonical Wnt signaling induced by Wnt3a by 50%, indicating that Wnt3a and Wnt5a have antagonistic effects on the canonical Wnt pathway in HSCs in vitro. [Method: Il-7Ralpha- KSL cells (isolated from TOPGAL mice) cultured with recombinant Wnt3a or Wnt5a]
Formal Description
Interaction-ID: 39001

gene/protein

Wnt5a

decreases_activity of

gene/protein

Wnt3a

in CD127-KSL cells in vitro