General Information:

Id: 3,403 (click here to show other Interactions for entry)
Mus musculus
C57BL/6 CD45.2/.1, 6 to 9 week-old; Angptl3 -/- mice or WT
Reference: Zheng J et al.(2011) Angiopoietin-like protein 3 supports the activity of hematopoietic stem cells in the bone marrow niche Blood 117: 470-479 [PMID: 20959605]

Interaction Information:

Comment CD45-SSEA4+ cells expressed a significantly greater amount of other HSC cytokines compared with CD45-SSEA4- cells. These factors included SCF, Notch ligands ( Delta-1 and Jagged-1), Wnt3a, SDF-1, IGFBP2 and Nestin. [Method: qRT-PCR]
Formal Description
Interaction-ID: 31637

tissue/cell line

BM cell (CD45-SSEA4+Angpt3+)

increases_expression of

gene/protein

Wnt3a

in comparison to CD45-SSEA4+ cells