General Information:

Id: 3,160 (click here to show other Interactions for entry)
Mus musculus
C57BL6 (B6; CD45.2 and CD45.1) and B6-Thy1.1 (PL), OP9 cell line, endothelioma cell line
Reference: Malhotra S and Kincade PW(2009) Canonical Wnt pathway signaling suppresses VCAM-1 expression by marrow stromal and hematopoietic cells Exp. Hematol. 37: 19-30 [PMID: 18951693]

Interaction Information:

Comment Temporary Wnt mediated down-regulation of VCAM-1 on hematopoietic cells does not prevent them from engrafting and differentiating following transplantation. Exposure to Wnt3a producing stromal cells enhanced rather than compromised the ability of hematopoietic cells to be transplanted. [Method: HSC (Thy1(lo)KSL) isolated from B6-Thy1.1 (PL) (CD45.2) mice pre-cultured on OP9-control or OP9-Wnt3a stromal cells for 5 d, transplantation, FACS analysis after 1 month]
Formal Description
Interaction-ID: 29080

gene/protein

Wnt3a

increases_activity of

process

repopulation <12 weeks

in vivo