General Information:

Id: 3,160 (click here to show other Interactions for entry)
Mus musculus
C57BL6 (B6; CD45.2 and CD45.1) and B6-Thy1.1 (PL), OP9 cell line, endothelioma cell line
Reference: Malhotra S and Kincade PW(2009) Canonical Wnt pathway signaling suppresses VCAM-1 expression by marrow stromal and hematopoietic cells Exp. Hematol. 37: 19-30 [PMID: 18951693]

Interaction Information:

Comment Wnt3a can inhibit VCAM-1 expression in hematopoietic cells (KSL). Co-culture of a VCAM-1 positive endothelioma cell line together with Wnt3a producing OP9 cells results in Wnt3a-dependent down-regulation of Vcam1. [Method: qRT-PCR with KSL cells cultured on Wnt3-secreting or control stromal cells; endothelioma cell line co-cultured with Wnt3a producing OP9 cell.
Formal Description
Interaction-ID: 29074

gene/protein

Wnt3a

decreases_expression of

gene/protein

Vcam1

in HSC (KSL) cells as well as in endothelioma cells in vitro
Drugbank entries Show/Hide entries for Vcam1