General Information:

Id: 3,158 (click here to show other Interactions for entry)
Mus musculus
OP9-Wnt3a secreting stromal cell or OP-9-control cells
Reference: Malhotra S and Kincade PW(2009) Canonical Wnt pathway signaling suppresses VCAM-1 expression by marrow stromal and hematopoietic cells Exp. Hematol. 37: 19-30 [PMID: 18951693]

Interaction Information:

Comment Hematopoietic cells formed very few cobblestones when cultured on Wnt3a transduced rather than wild-type stromal cells that do not make Wnt3a. [Method: cobblestone formation assay, OP9 stromal cells Wnt3a secreting or control]
Formal Description
Interaction-ID: 29052

gene/protein

Wnt3a

decreases_activity of

process

cobblestone formation

of HSC (KSL) in vitro
Comment In OP9-Wnt3a stromal cells the following genes involved in cell adhesion are differentially expressed in comparison to control OP9 cells. [Method: RT-PCR in OP9-Wnt3a or OP9-control cells]
Formal Description
Interaction-ID: 29053

gene/protein

Wnt3a

increases_expression of

gene/protein

Cdh2

in stromal cells
Comment In OP9-Wnt3a stromal cells the following genes involved in cell adhesion are differentially expressed in comparison to control OP9 cells. [Method: RT-PCR in OP9-Wnt3a or OP9-control cells]
Formal Description
Interaction-ID: 29054

gene/protein

Wnt3a

increases_expression of

gene/protein

Col1a1

in stromal cells
Drugbank entries Show/Hide entries for Col1a1
Comment In OP9-Wnt3a stromal cells the following genes involved in cell adhesion are differentially expressed in comparison to control OP9 cells. [Method: RT-PCR in OP9-Wnt3a or OP9-control cells]
Formal Description
Interaction-ID: 29055

gene/protein

Wnt3a

increases_expression of

gene/protein

Itga3

in stromal cells
Comment In OP9-Wnt3a stromal cells the following genes involved in cell adhesion are differentially expressed in comparison to control OP9 cells. [Method: RT-PCR in OP9-Wnt3a or OP9-control cells]
Formal Description
Interaction-ID: 29056

gene/protein

Wnt3a

increases_expression of

gene/protein

Mmp3

in stromal cells
Drugbank entries Show/Hide entries for Mmp3
Comment In OP9-Wnt3a stromal cells the following genes involved in cell adhesion are differentially expressed in comparison to control OP9 cells. [Method: RT-PCR in OP9-Wnt3a or OP9-control cells]
Formal Description
Interaction-ID: 29057

gene/protein

Wnt3a

increases_expression of

gene/protein

Postn

in stromal cells
Comment In OP9-Wnt3a stromal cells the following genes involved in cell adhesion are differentially expressed in comparison to control OP9 cells. [Method: RT-PCR in OP9-Wnt3a or OP9-control cells]
Formal Description
Interaction-ID: 29058

gene/protein

Wnt3a

increases_expression of

gene/protein

Thbs2

in stromal cells
Comment In OP9-Wnt3a stromal cells the following genes involved in cell adhesion are differentially expressed in comparison to control OP9 cells. [Method: RT-PCR in OP9-Wnt3a or OP9-control cells]
Formal Description
Interaction-ID: 29059

gene/protein

Wnt3a

increases_expression of

gene/protein

Timp3

in stromal cells
Comment In OP9-Wnt3a stromal cells the following genes involved in cell adhesion are differentially expressed in comparison to control OP9 cells. [Method: RT-PCR in OP9-Wnt3a or OP9-control cells]
Formal Description
Interaction-ID: 29060

gene/protein

Wnt3a

decreases_expression of

gene/protein

Col4a1

in stromal cells
Comment In OP9-Wnt3a stromal cells the following genes involved in cell adhesion are differentially expressed in comparison to control OP9 cells. [Method: RT-PCR in OP9-Wnt3a or OP9-control cells]
Formal Description
Interaction-ID: 29061

gene/protein

Wnt3a

decreases_expression of

gene/protein

Vcan

in stromal cells
Comment In OP9-Wnt3a stromal cells the following genes involved in cell adhesion are differentially expressed in comparison to control OP9 cells. [Method: RT-PCR in OP9-Wnt3a or OP9-control cells]
Formal Description
Interaction-ID: 29062

gene/protein

Wnt3a

decreases_expression of

gene/protein

Icam1

in stromal cells
Drugbank entries Show/Hide entries for Icam1
Comment In OP9-Wnt3a stromal cells the following genes involved in cell adhesion are differentially expressed in comparison to control OP9 cells. [Method: RT-PCR in OP9-Wnt3a or OP9-control cells]
Formal Description
Interaction-ID: 29063

gene/protein

Wnt3a

decreases_expression of

gene/protein

Itga2

in stromal cells
Comment In OP9-Wnt3a stromal cells the following genes involved in cell adhesion are differentially expressed in comparison to control OP9 cells. [Method: RT-PCR in OP9-Wnt3a or OP9-control cells]
Formal Description
Interaction-ID: 29064

gene/protein

Wnt3a

decreases_expression of

gene/protein

Itga4

in stromal cells
Drugbank entries Show/Hide entries for Itga4
Comment In OP9-Wnt3a stromal cells the following genes involved in cell adhesion are differentially expressed in comparison to control OP9 cells. [Method: RT-PCR in OP9-Wnt3a or OP9-control cells]
Formal Description
Interaction-ID: 29065

gene/protein

Wnt3a

decreases_expression of

gene/protein

Itgb2

in stromal cells
Drugbank entries Show/Hide entries for Itgb2
Comment In OP9-Wnt3a stromal cells the following genes involved in cell adhesion are differentially expressed in comparison to control OP9 cells. [Method: RT-PCR in OP9-Wnt3a or OP9-control cells]
Formal Description
Interaction-ID: 29066

gene/protein

Wnt3a

decreases_expression of

gene/protein

Itgb3

in stromal cells
Drugbank entries Show/Hide entries for Itgb3
Comment In OP9-Wnt3a stromal cells the following genes involved in cell adhesion are differentially expressed in comparison to control OP9 cells. [Method: RT-PCR in OP9-Wnt3a or OP9-control cells]
Formal Description
Interaction-ID: 29067

gene/protein

Wnt3a

decreases_expression of

gene/protein

Mmp13

in stromal cells
Drugbank entries Show/Hide entries for Mmp13
Comment In OP9-Wnt3a stromal cells the following genes involved in cell adhesion are differentially expressed in comparison to control OP9 cells. [Method: RT-PCR in OP9-Wnt3a or OP9-control cells]
Formal Description
Interaction-ID: 29068

gene/protein

Wnt3a

decreases_expression of

gene/protein

Spp1

in stromal cells
Comment In OP9-Wnt3a stromal cells the following genes involved in cell adhesion are differentially expressed in comparison to control OP9 cells. [Method: RT-PCR in OP9-Wnt3a or OP9-control cells]
Formal Description
Interaction-ID: 29069

gene/protein

Wnt3a

decreases_expression of

gene/protein

Vcam1

in stromal cells
Drugbank entries Show/Hide entries for Vcam1