General Information:

Id: 2,878 (click here to show other Interactions for entry)
Mus musculus
transgenic C57Bl/6 mice (8-12 weeks), constitutively expressing secreted Wif1 (pCol1alpha 1-Wif1)
Reference: Schaniel C et al.(2011) Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells Blood 118: 2420-2429 [PMID: 21652676]

Interaction Information:

Comment The following genes are overexpressed in HSC (CD34-KSL) of Wif1-mice. [Method: qRT-PCR, HSC (CD34-KSL) from Wif1 and control OB mice]
Formal Description
Interaction-ID: 26529

Immunophenotype

HSC (CD34-KSL)

increases_expression of

gene/protein

Wnt3a

in Wif1-overexpressing osteoblasts.  in vivo
Comment The following genes are overexpressed in HSC (CD34-KSL) of Wif1-mice. [Method: qRT-PCR, HSC (CD34-KSL) from Wif1 and control OB mice]
Formal Description
Interaction-ID: 26552

gene/protein

Wif1

increases_expression of

gene/protein

Wnt3a

in HSC (CD34-KSL), if Wif1-overexpressing osteoblasts are present  in vivo
Comment Wnt3a is a component of the Wnt signaling process. [Method: cited information]
Formal Description
Interaction-ID: 26566

gene/protein

Wnt3a

increases_activity of