Immunostaining of hematopoietic stem and progenitor cells: CD45-a488 (green), sca1a555 (blue), cKita647 (white) (provided by Dirk Loeffler).
HSC-Explorer is a manually curated integrative
bioinformatics resource based on semantic search and ontologies
that allow to effectively search biological pathways relevant to
Specifically, the database currently
covers the early steps of differentiation from the most primitive
hematopoietic stem cells (LT-HSC) to the more differentiated
progenitor cells (ST-HSC and MPP). Curated literature information
about the different hematopoietic stem cell subpopulations
published so far and their behavior in repopulation activity,
self-renewal and quiescence and how these processes are regulated
by intrinsic and extrinsic factors is provided.
an effective query function relevant information can be easily
extracted and the data can be graphically visualized.
constantly work on expanding the current database to ultimately
cover all hematopoietic progenitor populations.
of HSC-Explorer is to serve as a knowledge base for
experimentally-oriented scientists and as a resource for